摘要
目的:研究糖尿病肾病患者抑郁情绪对肾功能以及氧化应激反应、炎症反应的影响。方法:选择在我院接受治疗的单纯2型糖尿病患者、糖尿病肾病患者、糖尿病肾病合并抑郁患者作为研究对象,分别纳入单纯糖尿病组、糖尿病肾病组、合并抑郁组,测定肾功能指标、氧化应激反应指标、炎症反应指标。结果:合并抑郁组、糖尿病肾病组血清中Scr、BUN、CysC、ROS、MDA、8-OHdG、IL-6、IL-18、MCP-1、ICAM-1、TNF-α含量以及尿液中MA、A1M含量均显著高于单纯糖尿病组,血清中Mn-SOD、CAT、GSH-Px、T-AOC的含量均显著低于单纯糖尿病组;合并抑郁组血清中Scr、BUN、CysC、ROS、MDA、8-OHdG、IL-6、IL-18、MCP-1、ICAM-1、TNF-α含量以及尿液中MA、A1M含量均显著高于糖尿病肾病组,血清中Mn-SOD、CAT、GSH-Px、T-AOC的含量均显著低于糖尿病肾病组。HAMD评分与血清中Scr、BUN、CysC、ROS、MDA、8-OHdG、IL-6、IL-18、MCP-1、ICAM-1、TNF-α含量以及尿液中MA、A1M含量呈正相关,与血清中Mn-SOD、CAT、GSH-Px、T-AOC含量呈负相关。结论:糖尿病肾病患者抑郁情绪会加重肾功能损伤,加剧氧化应激反应和炎症反应。
Objective：To study the effect of depression on renal function as well as oxidative stress and inflammatory response in patients with diabetic nephropathy.Methods：Patients with type 2diabetes alone,patients with diabetic nephropathy and patients with diabetic nephropathy and depression treated in our hospital between May 2014 and September 2016 were selected as the research subjects and included in simple diabetes group,diabetic nephropathy group and complicated depression group,and the renal function indexes,oxidative stress indexes and inflammatory response indexes were detected.Results：Scr,BUN,CysC,ROS,MDA,8-OHdG,IL-6,IL-18,MCP-1,ICAM-1,and TNF-αlevels in serum as well as MA and A1 Mlevels in urine of complicated depression group and diabetic nephropathy group were significantly higher than those of simple diabetes group while serum Mn-SOD,CAT,GSH-Px and T-AOC levels were significantly lower than those of simple diabetes group;Scr,BUN,CysC,ROS,MDA,8-OHdG,IL-6,IL-18,MCP-1,ICAM-1,and TNF-αlevels in serum as well as MA and A1 Mlevels in urine of complicated depression group were significantly higher than those of diabetic nephropathy group while serum Mn-SOD,CAT,GSH-Px and T-AOC levels were significantly lower than those of diabetic nephropathy group.HAMD score was positively correlated with Scr,BUN,CysC,ROS,MDA,8-OHdG,IL-6,IL-18,MCP-1,ICAM-1and TNF-αlevels in serum as well as MA and A1 Mlevels in urine,and negatively correlated with Mn-SOD,CAT,GSH-Px and TAOC levels in serum.Conclusion：Depression in patients with diabetic nephropathy can aggravate the renal injury and increase oxidative stress and inflammatory response.
出处
《海南医学院学报》
CAS
2017年第5期701-704,共4页
Journal of Hainan Medical University
基金
创新培育基金(CXPY201503)~~
关键词
糖尿病肾病
抑郁
氧化应激反应
炎症反应
Diabetic nephropathy
Depression
Oxidative stress response
Inflammatory response
