摘要
目的:观察不同降糖方案对2型糖尿病(T2DM)患者血清炎症因子及血液高凝状态的影响。方法:187例T2DM病例依据降糖方案的不同分为3组,分别设为胰岛素组(69例)、口服药组(58例)和联合组(60例)。胰岛素组采用门冬胰岛素30皮下注射,口服药组采用二甲双胍、格列吡嗪口服,联合组采门冬胰岛素30皮下注射联合二甲双胍口服。治疗6个月,观察3组炎症反应指标(hs-CRP、TNF-α、IL-6、MCP-1)、凝血功能相关指标(PT、APTT、TT、FIB以及PLT、TXB2)水平的差异。结果:治疗后,3组TNF-α、hs-CRP、IL-6、MCP-1均明显下降(P<0.05),两两比较显示:联合组分别与胰岛素组、口服药组各指标比较差异有统计学意义(P<0.05),胰岛素组与口服药组各指标比较差异无统计学意义(P>0.05);治疗后,3组除PLT无明显变化外,PT、TT、APTT均明显上升而FIB、TXB2均明显下降(P<0.05),两两比较显示:联合组分别与胰岛素组、口服药组各指标比较差异有统计学意义(P<0.05),胰岛素组与口服药组各指标比较差异无统计学意义(P>0.05)。结论:3种降糖方案均有利于降低炎症反应以及缓解血液高凝状态,但胰岛素联合口服药效果最佳。
Objective：To observe the effect of different hypoglycemic scheme on serum inflammatory factors and blood hypercoagulability in patients with type 2 diabetes mellitus （T2DM）.Methods：A total of 186 cases with T2DM were randomly divided into 3 groups according to the different hypoglycemic scheme,such as：insulin group （69 cases）,oral drug group （58 cases）and combination group （60 cases）.Insulin group was given insulin aspart;oral drug group was given metformin and pio-glitazone;combination group was given insulin aspart and metformin.For 6 mouths,to observe the different of serum inflam-matory factors （TNF-α,hs-CRP,IL-6,MCP-1）and blood hypercoagulabilit indexes （PT,APTT,TT,FIB,PLT,TXB2）be-tween the three groups.Results：After treatment,TNF-α,hs-CRP,IL-6,MCP-1 of the three groups were decreased with before （P 〈0.05）,pairwise comparisons showed that：each index of the combination group had statistical significance with those of insulin group and oral drug group （P 〈0.05）;there was no significant difference in insulin group and oral drug group （P 〉0.05）.After treatment,except PLT was no change,PT,APTT,TT of the three groups were increased and FIB,TXB2 were decreased with before （P 〈0.05）,pairwise comparisons showed that：each index （excepted PLT）of the combination group had statistical significance with those of insulin group and oral drug group （P 〈0.05）;there was no significant difference in insulin group and oral drug group （P 〉0.05）.Conclusions：All of the 3 hypoglycemic schemes are beneficial to reduce the inflammato-ry reaction and relieve the blood hypercoagulability,but the effect of insulin combined with oral drug is the best.
出处
《海南医学院学报》
CAS
2016年第21期2637-2640,共4页
Journal of Hainan Medical University
基金
陕西省科技计划项目(SJ12H409)~~
关键词
2
型糖尿病
降糖方案
炎症因子
血液高凝状态
Type 2 diabetes mellitus
Hypoglycemic scheme
Serum inflammatory factors
Blood hypercoagulability
