摘要
目的分析溃疡性结肠炎（UC）患儿凝血酶原时间（PT）、活化部分凝血活酶时间（APTT））、纤维蛋白原（FIB）、D-二聚体（DD）、抗凝血酶Ⅲ（ATⅢ）和血小板（PLT）诊断指标的临床价值，探寻评估UC患儿病情及严重程度的有效指标。方法分析2012年1月至2016年9月在南京医科大学附属儿童医院消化科住院的UC患儿资料，选择25例缓解期、36例活动期UC患儿为研究对象，选取本院同期30例健康体检儿童为健康对照组，结合凝血功能指标进行分析。结果UC患儿PT、APTT、FIB、DD、ATⅢ和PLT的受试者工作特征曲线下面积（AUC）分别为0.659、0.840、0.744、0.776、0.599和0.792，活动期UC患儿AUC分别为0.849、0.889、0.836、0.912、0.964和0.966。活动期组UC患儿PT、APTT、FIB、DD和PLT的检测结果明显高于健康对照组，ATⅢ明显低于健康对照组；缓解期UC患儿各凝血指标与健康对照组比较差异无统计学意义（P〉0.05）；UC患儿不同病情程度间PT和APTT检测结果比较差异均无统计学意义（F＝0.652、1.755，均P〉0.05），而FIB、DD、ATⅢ和PLT检测结果比较差异均有统计学意义（F＝66.495、32.817、88.284、22.892，均P〈0.05），FIB、DD和PLT与病情严重程度呈中度正相关（r＝0.857、0.648、0.654，均P〈0.05），而ATⅢ与病情严重程度呈中度负相关（r＝－0.789，P〈0.05）；回归分析显示UC患儿病情程度与FIB、DD和ATⅢ相关（R2＝0.830，F＝39.962，P〈0.05）。结论FIB、DD和ATⅢ可作为评估UC患儿病情及其严重程度的指标，对临床评价UC患儿病情具有一定的参考价值。
Objective To explore the diagnostic value of prothrombin time （PT）, activated partial thromboplastin time （ April）, fibrinogen （ FIB ）, D - Dimer （ DD ）, antithrombin m （ AT Ⅲ ）, platelet （PLT） in activity and severity assessment of ulcerative colitis （UC） , and to analyze whether they could evaluate the degree of activity UC in children. Methods The data of UC patients in the Department of Gastroenterology, Children＇s Hospital of Nanjing Medical University from January 2012 to September 2016 were analyzed,25 cases of remission and 36 cases of active UC patients were selected as the study subjects. Thirty healthy children were selected as healthy control group, combined with the coagulation function indicators for analysis. Results Receiver operating characteristic area under the curve （AUC） of PT, APTT, FIB, DD, AT Ⅲ and PLT in UC patients was 0. 659,0. 840,0. 744,0. 776,0. 599 and 0. 792 ,the activity of UC patients was 0.849,0. 889,0. 836,0.912,0.964 and 0. 966, respectively. The results of PT, APTT,FIB,DD and PLT in children with active UC were significantly higher than those in the healthy control group, and AT Ⅲ was significantly lower than that in the healthy control group. Compared with the healthy controls,the levels in remission UC patients were not significantly different（ P 〉0.05 ）. The 3 subgroups of activity UC had no significant differences among PT and APTT（ F = 0. 652,1. 755, all P 〉 0.05 ）, However, there were significant differences among FIB, DD, AT m and PLT （ F = 66.495,32.817,88. 284,22.892, all P 〈 0.05 ）. FIB, DD and PLT were moderately positively correlated with severity of activity UC patients（ r = 0. 857,0. 648,0.654, all P 〈 0.05 ）, and ATm had moderately negative correlation （r = -0. 789, P 〈 0. 05 ）. Progressive regression analysis showed that the severity of UC was associated with FIB, DD and ATⅢ （R2 = 0. 830, F = 39. 962,P 〈 0.05 ）. Conclusion FIB, DD and AT Ⅲ can be used as index for the activity and
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2017年第7期513-515,共3页
Chinese Journal of Applied Clinical Pediatrics
关键词
溃疡性结肠炎
诊断
儿童
Ulcerative colitis
Diagnosis
Child
