摘要
目的探究奥美拉唑联合肠道微生态调节剂对新生儿坏死性小肠结肠炎(NEC)症状改善及免疫功能的影响。方法对我院2015年2月—2019年5月NEC患儿78例临床资料进行回顾性分析。对照组(n=39)给予肠道微生态调节剂治疗,观察组(n=39)于对照组基础上加用奥美拉唑。对比两组疗效、症状改善时间(腹泻改善、腹胀改善、大便恢复正常)及治疗前后T细胞亚群水平(CD4^+、CD4^+/CD8^+)、血清炎性因子[C反应蛋白(CRP)、白介素6(IL-6)]水平。结果观察组总有效率较对照组高(P<0.05);观察组症状改善时间较对照组短(P<0.05);治疗后观察组CD4^+、CD4^+/CD8^+较对照组高(P<0.05);治疗后观察组血清CRP、IL-6水平较对照组低(P<0.05)。结论奥美拉唑联合肠道微生态调节剂治疗NEC患儿,可促进症状改善,调节免疫功能,减轻炎症,效果显著。
Objective To investigate the effect of Omeprazole combined with intestinal microecological regulator on the improvement of neonatal necrotizing enterocolitis(NEC)symptoms and immune function.Methods The clinical data of 78 neonates with NEC cared in our hospital from February 2015 to May 2019 were analyzed retrospectively.The control group(39 cases)was treated with intestinal microecological regulator,and the observation group(39 cases)was given Omeprazole on the basis of the control group.The efficacy,time of symptom improvement(improvement of diarrhea,improvement of abdominal distension and normal stools),and the T cell subsets(CD4^+,CD4^+/CD8^+)levels,serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The time of symptom improvement in the observation group was shorter than that of the control group(P<0.05).After treatment,CD4^+ and CD4^+/CD8^+ in the observation group were higher than those of the control group(P<0.05),serum CRP and IL-6 levels in the observation group were lower than those in the control group(P<0.05).Conclusion Omeprazole combined with intestinal microecological regulator in the treatment of children with NEC can promote the improvement of symptoms,regulate immune function,reduce inflammation,and the effect is significant.
作者
胥彬
Xu Bin(Department of Neonatology,the First People’s Hospital of Xinxiang,Xinxiang 453000,Henan,China)
出处
《右江民族医学院学报》
2020年第3期321-323,共3页
Journal of Youjiang Medical University for Nationalities
关键词
奥美拉唑
肠道微生态调节剂
小肠结肠炎
坏死性
婴儿
新生
Omeprazole
intestinal microecological regulator
enterocolitis,necrotizing
infant
newborn
