摘要
目的观察自拟脑府逐瘀汤治疗急性脑出血吸收期的临床疗效。方法将患者140例按照随机数字表法分为研究组和对照组,各70例,对照组给予常规西药治疗,研究组在对照组的基础上给予自拟脑府逐瘀汤治疗,应用美国国立卫生院神经功能缺损评分(NIHSS)评价神经功能缺损情况,比较两组临床疗效,比较治疗前后红细胞变形性和聚集性、血液流变学指标、自由基指标及中医证候积分。结果研究组总有效率88.57%显著高于对照组的75.71%(P<0.05);治疗后两组红细胞变形性显著增加,红细胞聚集性显著降低,研究组显著优于对照组(P<0.05);治疗后两组血液流变学指标均显著降低,且研究组低于对照组(P<0.05);治疗后两组超氧化物歧化酶(SOD)和过氧化氢酶(CTA)显著增高,MDA显著降低,且研究组显著优于对照组(P<0.05);治疗后两组中医证候积分、NIHSS评分显著降低,且研究组低于对照组(P<0.05)。结论自拟脑府逐瘀汤治疗急性脑出血吸收期具有较好的临床疗效,能显著改善患者自由基代谢指标血液流变学指标及中医证候积分。
Objective： To study the effect of Naofu zhuyu decoction on acute cerebral hemorrhage of absorption phase. Methods： 140 cases in absorption phase of acute cerebral hemorrhage from January 2014 to January 2016 were randomly divided into the observation group and the control group,70 cases in each. The control group was given conventional western medicine treatment,while the observation group added Naofu zhuyu decoction. NIHSS was used to evaluate neurological deficits. The clinical effect,erythrocyte deformability and aggregation before and after treatment,hemorrheology indexes,Free radical indexes and TCM syndrome integral were compared. Results：The total effective rate of the observation group was 88.57%,significantly higher than that of the control group75.71%（P〈0.05）. After treatment,red cell deformability increased significantly;red cell aggregation decreased significantly;the observation group was significantly better than the control group（P〈0.05）. Hemorrheology indexes decreased significantly,and the observation group was significantly lower than the control group（P〈0.05）.SOD and CTA decreased significantly,and the observation group was significantly better than the control group（P〈0.05）. TCM syndrome integral and NIHSS scores decreased significantly,and the observation group was significantly lower than the control group（P〈0.05）. Conclusion： Naofu zhuyu decoction has a better clinical effect on acute cerebral hemorrhage of absorption phase,and can significantly improve free radical metabolic index,hemorheology and TCM syndrome integral.
出处
《中国中医急症》
2017年第2期343-345,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
大连市卫生局科研基金项目(WSJ/KJC-01-JL-01)
关键词
脑府逐瘀汤
急性脑出血
自由基
血液流变学
中医证候积分
Naofu zhuyu decoction
Acute cerebral hemorrhage
Free radical
Hemorheology
TCM syndrome integral
