摘要
目的探讨白虎汤加味联合小牛血清去蛋白对脑出血急性期血清超敏C反应蛋白以及血浆S100β蛋白的影响。方法将2015年5月—2018年1月医院脑出血急性期患者72例,随机分两组,各36例,均采用脑出血急性期治疗措施,对照组采用小牛血清去蛋白注射液20 mL静脉滴注;观察组采用白虎汤加味日一剂联合小牛血清去蛋白20 mL静脉滴注,持续治疗2周。比较两组患者的疗效,治疗前、治疗1周和治疗2周时测定血清高敏C反应蛋白(High-sensitivity C-reactive protein,hs-CRP)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及血浆S100β蛋白。结果两组患者在性别、平均年龄、平均病程及平均出血量比较,差异无统计学意义(P>0.05)。对照组有效率72.22%(26/36)与观察组91.67%(33/36)比较,差异具有统计学意义(P<0.05)。与治疗前比,两组患者治疗1周、治疗2周血S100β蛋白、hs-CRP水平降低;与对照组比,观察组患者治疗1周、治疗2周血S100β蛋白、hs-CRP水平较低,差异具有统计学意义(P<0.05)。与治疗前比,两组患者治疗1周、治疗2周血清IL-6、TNF-α水平降低;与对照组比,观察组患者治疗1周、治疗2周血清IL-6、TNF-α水平较低,差异具有统计学意义(P<0.05)。对照组2例水电解质紊乱,观察组无不良反应出现。结论白虎汤加味联合小牛血清去蛋白对脑出血急性期患者的疗效确切,降低血hs-CRP、S100β蛋白及炎症因子,且安全性高。
Objective To investigate the effects of Modified Baihu Decoction combined with deproteinised calf serum on hypersensitive C-reactive protein and plasma S100βprotein in serum of cerebral hemorrhage in the acute stage.Methods Seventy-two patients with acute cerebral hemorrhage from May 2015 to January 2018 were randomly divided into two groups,36 cases in each group.The control group received deproteinised calf serum 20 mL once a day by intracutaneous injection while the observation group received Modified Baihu Decoction and deproteinised calf serum injection 20 mL once a day by intracutaneous injection.The therapeutic effects were compared between the two groups.Serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-alpha)and plasma S100βprotein were measured before treatment,1 and 2 weeks after treatment.Results There was no significant difference in gender,average age,average course of disease or average amount of bleeding between the two groups(P>0.05).The effective rate of the control group72.22%(26/36)was lower than that of the observation group 91.67%(33/36)and the difference was statistically significant(P<0.05).Compared with those before treatment,the levels of serum S100βprotein and hs-CRP in the two groups were lower after 1 and 2 weeks treatment,and the levels of serum S100βprotein and hs-CRP in the observation group were lower(P<0.05).Compared with those before treatment,the levels of IL-6 and TNF-alpha in serum of the two groups were lower after 1 and 2 weekstreatment,and those of the observation group were lower than those of the control group(P<0.05).Two cases in the control group had electrolyte disturbance,and no adverse reactions occurred in the observation group.Conclusion Modified Baihu Decoction combined with deproteinised calf serum is effective on treating acute cerebral hemorrhage.It can reduce hs-CRP,S100βprotein and inflammatory factors with high safety.
作者
王小言
夏鹰
金虎
陈伟明
陈晓东
聂柳
郑忠涛
林捷
WANG Xiaoyan;XIA Ying;JIN Hu;CHEN Weiming;CHEN Xiaodong;NIE Liu;ZHENG Zhongtao;LIN Jie(Department of Neurosurgery,Haikou People’s Hospital,Haikou 570208,Hainan,China;Department of Traditional Chinese Medicine,Haikou People’s Hospital,Haikou 570208,Hainan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期222-225,共4页
Chinese Archives of Traditional Chinese Medicine
基金
海南省卫生和计划生育委员会科研项目(琼卫2011-57)。
关键词
白虎汤加味
小牛血清去蛋白
脑出血急性期
超敏C反应蛋白
S100Β蛋白
Modified Baihu Decoction
deproteinised calf serum
cerebral hemorrhage in acute stage
hypersensitive C-reactive protein
S100βprotein
