摘要
目的探讨大剂量甲泼尼龙冲击治疗对自发性脑出血后脑水肿患者的治疗效果及其生活能力的影响。方法研究对象选择2019年1月-2021年10月在本院接受治疗的86例自发性脑出血后的脑水肿患者,将其随机分成观察组(n=43例)和对照组(n=43例)。对照组予以甘露醇治疗,观察组采用大剂量甲泼尼龙冲击治疗,比较两组患者治疗后ADL评分、脑出血量及脑水肿面积、神经功能缺损的程度以及不良反应发生率。结果经治疗,观察组患者的进食、洗澡、上下楼梯等各项评分均高于对照组,差异有统计学意义(P<0.05)。两组治疗后,观察组脑出血量及脑水肿面积低于对照组,差异有统计学意义(P<0.05)。两组治疗前神经功能缺损程度对比差异不具有统计学意义(P>0.05);治疗后,观察组患者神经功能缺损程度与对照组相比较低,差异有统计学意义(P<0.05)。观察组治疗后出现应激性溃疡、血糖升高的总不良反应发生率23.26%低于对照组51.16%,差异有统计学意义(P<0.05)。结论大剂量甲泼尼龙冲击治疗对自发性脑出血后脑水肿患者的效果显著,提升生活能力评分,改善患者神经功能缺损程度,降低不良反应发生率,利于病情好转,值得推广和应用。
Objective To explore effect of high-dose methylprednisolone pulse therapy on patients with cerebral edema after spontaneous cerebral hemorrhage and its influence on their living ability.Methods The paper chose 86 patients with brain edema after spontaneous intracerebral hemorrhage treated in our hospital from January 2019 to October 2021,and divided them into observation group(n=43 cases)and control group(n=43 cases)randomly.Control group was treated with mannitol,and observation group with high-dose methylprednisolone pulse therapy.ADL scores,amount of cerebral hemorrhage,brain edema area,degree of neurological deficit and adverse reactions incidence was compared between two groups.Results After treatment,scores of eating,bathing,going up and down stairs in observation group were significantly higher than control group,difference was statistically significant,(P<0.05).After treatment,amount of cerebral hemorrhage and brain edema area in observation group was significantly less than control group,difference was statistically significant,(P<0.05).There was no significant difference in nerve function defect degree between two groups before treatment(P>0.05).After treatment,nerve function defect degree in observation group was lower than control group,difference was statistically significant(P<0.05).Total adverse reaction rate of stress ulcer and elevated blood glucose in observation group after treatment was 23.26%,lower than control group(51.16%),difference was statistically significant(P<0.05).Conclusion High-dose methylprednisolone pulse therapy can achieve significant effect on patients with cerebral edema after spontaneous intracerebral hemorrhage,can improve life ability scores,neurological impairment degree,reduce adverse reactions incidence,and improve condition of patients,which is worthy promotion and application.
作者
杨来
YANG Lai(Neurology Department,Baoying Eryuan Hospital,Yangzhou,Jiangsu 225800)
出处
《智慧健康》
2023年第3期116-119,124,共5页
Smart Healthcare
关键词
大剂量甲泼尼龙冲击治疗
甘露醇
自发性脑出血后脑水肿
生活能力
不良反应发生率
High-dose methylprednisolone pulse therapy
Mannitol
Cerebral edema patients after spontaneous intracerebral hemorrhage
Living ability
Adverse reaction incidence
