摘要
目的分析研究自发性脑出血后继发性脑水肿患者的临床治疗方式。方法将新疆生产建设兵团第十三师红星医院于2019年1月-2021年12月接收的自发性脑出血后继发性脑水肿患者100例作为观察对象,按照随机数字表法将患者分为观察组和对照组,各50例。对照组患者采取常规治疗措施;观察组患者在对照组基础上采取吡拉西坦联合甘露醇治疗。对比分析两组患者分别治疗后的临床疗效、临床症状改善时间、血肿及血肿体积变化、NIHSS评分、mRS评分以及血清凝血酶、MMP-9水平变化。结果在两组患者分别治疗后分析患者的临床疗效可见,观察组明显更高,对比有统计学差异(P<0.05);在两组患者分别治疗后分析临床症状改善时间可见,观察组明显更短(P<0.05);在两组患者治疗前分析血肿及血肿体积变化可见,两组并无明显差异(P>0.05),而在两组患者分别治疗后分析可见,观察组降低更明显(P<0.05);在两组患者分别治疗前分析NIHSS评分、mRS评分可见,两组患者并无明显差异(P>0.05),但在两组患者分别治疗后分析可见,观察组评分降低更明显(P<0.05);分析两组患者治疗前的血清凝血酶、MMP-9水平可见,两组并无明显差异(P>0.05),但在患者治疗后分析可见,观察组降低更明显(P<0.05)。结论在自发性脑出血后继发性脑水肿患者的临床治疗中,采取吡拉西坦联合甘露醇更有利于提高患者治疗疗效,减轻患者神经功能缺损程度,相较于常规治疗措施更有利于患者血肿清除,值得临床广泛应用。
Objective To analyze and study the clinical treatment of secondary brain edema after spontaneous intracerebral hemorrhage.Methods One hundred patients with secondary brain edema after spontaneous intracerebral hemorrhage treated in Hongxing Hospital of the 13th Division of Xinjiang Production and Construction Corps from January 2019 to December 2021 were observed.The patients were randomly divided into observation group and control group,with 50 cases in each group.The patients in the control group took routine treatment measures.The patients in the observation group were treated with Piracetam combined with mannitol on the basis of the control group.The clinical efficacy,clinical symptom improvement time,hematoma and hematoma volume changes,NIHSS score,mRS score,serum thrombin and MMP-9 levels of the two groups were compared and analyzed.Results After the treatment of the two groups,the clinical efficacy of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference between the two groups in terms of hematoma and hematoma volume changes(P>0.05),but after treatment,it was more obvious in the observation group(P<0.05).The NIHSS score and mRS score of the two groups were analyzed before treatment.There was no significant difference between the two groups(P>0.05),but the score of the observation group decreased more significantly after treatment(P<0.05).Analysis of the levels of serum thrombin and MMP-9 in the two groups before treatment showed that there was no significant difference between the two groups(P>0.05),but it was more obvious in the observation group after treatment(P<0.05).Conclusion In the clinical treatment of patients with secondary brain edema after spontaneous intracerebral hemorrhage,Piracetam combined with mannitol is more conducive to improve the therapeutic effect and reduce the degree of neurological deficit. Compared with conventional treatment, it is more conducive to the removal of hematoma in patients, which is
作者
张英国
ZHANG Yingguo(Hongxing Hospital of the 13th Division of Xinjiang Production and Construction Corps,Hami,Xinjiang,839000)
出处
《智慧健康》
2022年第17期65-69,共5页
Smart Healthcare
关键词
自发性
脑出血
继发性脑水肿
Spontaneity
Cerebral hemorrhage
Secondary brain edema
