摘要
目的探讨康复新液联合美沙拉嗪治疗溃疡性结肠炎(UC)的临床疗效。方法 64例轻中度UC患者,随机分为对照组和治疗组,各32例。两组均给予益生菌辅助治疗,对照组在此基础上采用美沙拉嗪治疗,治疗组采用美沙拉嗪联合康复新液保留灌肠治疗。治疗8周后观察对比临床疗效。结果治疗组完全缓解20例(62.50%),有效10例(31.25%),无效2例(6.25%),总有效率为93.75%;对照组完全缓解13例(40.63%),有效11例(34.38)%,无效8例(25.00%),总有效率为75.00%;两组患者临床症状总有效率比较差异有统计学意义(P<0.05)。治疗组完全缓解20例(62.50%),有效11例(34.38%),无效1例(3.13%),总有效率为96.88%;对照组完全缓解15例(46.88%),有效11例(34.38%),无效6例(18.75%),总有效率为81.25%;两组患者内镜下检查总有效率比较差异有统计学意义(P<0.05)。结论康复新液灌肠联合美沙拉嗪治疗UC,其疗效显著、确切而且安全,值得临床推广。
Objective To investigate clinical effect by Kangfuxin liquid combined with mesalazine in the treatment of ulcerative colitis（UC）. Methods A total of 64 patients with moderate UC were randomly divided into control group and treatment group, with 32 cases in each group. Both groups received probiotics for adjuvant therapy. The control group also received mesalazine, while the treatment group received mesalazine combined with Kangfuxin liquid for retention enema. Observation and comparison was made on clinical effects between the two groups after 8 weeks of treatment. Results The treatment group had 20 complete remission cases（62.50%）, 10 effective cases（31.25%）and 2 ineffective cases（6.25%）, with total effective rate as 93.75%. The control group had 13 complete remission cases（40.63%）, 11 effective cases（34.38%）and 8 ineffective cases（25.00%）, with total effective rate as 75.00%. The difference of total effective rate of clinical symptoms had statistical significance between the two groups（P〈0.05）. The treatment group had 20 complete remission cases（62.50%）, 11 effective cases（34.38%）and 1 ineffective case（3.13%）, with total effective rate as 96.88%. The control group had 15 complete remission cases（46.88%）, 11 effective cases（34.38%）and 6 ineffective cases（18.75%）, with total effective rate as 81.25%. The difference of total effective rate of endoscopic examination had statistical significance between the two groups（P〈0.05）. Conclusion Combination of Kangfuxin liquid and mesalazine shows excellent curative effect and precise safety in treating UC, and this method is worth clinical promotion.
出处
《中国实用医药》
2016年第33期136-137,共2页
China Practical Medicine
