摘要
目的分析ICSI周期中父方年龄及精子来源与临床结局的关系。方法回顾性分析2012年1月至2015年12月在本中心进行ICSI且女方年龄在30~34岁的患者,总例数为489例。将患者按是否临床妊娠分组,分析父方年龄(<30岁、30~40岁、>40岁)和精子来源(精液精子、附睾精子、睾丸精子)对于临床妊娠结局的影响。结果临床妊娠组有348例,未临床妊娠组有141例;临床妊娠组与未妊娠组一般情况如女方年龄、基础FSH、体重指数、内膜厚度、可利用胚胎率等均无统计学差异(P>0.05);以是否临床妊娠作为因变量,精子来源和父方年龄作为自变量,进行回归分析,结果显示精子来源与临床妊娠无统计学相关性(P>0.05),而父方年龄与临床妊娠相关(P<0.05);不同父方年龄组的一般情况均无统计学差异(P>0.05),而随着父方年龄的增长,种植率和临床妊娠率呈现显著下降的趋势(P<0.05)。结论在ICSI周期中,随着父方年龄的增长,ICSI的临床妊娠率下降,而精子来源并不影响临床结局。
Objective： To investigate the effect of paternal age and sperm source on outcomes of ICSI. Methods： The data of 489 ICSI cycles in our center from January 2012 to December 2015 were respectively analyzed. The maternal age was between 30-34 years. The patients were grouped according to whether clinical pregnancy happened in order to analyze the effect of the paternal age （〈30 years, 30 to 40 years, 〉40 years） and sperm source （semen sperm, epididymal sperm, testicular sperm） on clinical outcomes. Results： There were 348 patients in pregnancy group and 141 patients in non-pregnancy group. There were no significant differences in age, body mass index, baseline hormone levels, endometrial thickness and available embryo rate between the two groups （P〉0.05）. Then regression analysis was performed using the clinical pregnancy as the dependent variable and sperm source and paternal age as independent variables. The results of regression analysis showed that sperm source and clinical pregnancy had no significant correlation （P 〉 O. 05）, while the paternal age was significantly associated with clinical pregnancy （P〈0.05）. Conclusions： In the ICSI cycle, the clinical pregnancy rate decreases along with increasing paternal age, while sperm source does not affect clinical outcomes.
出处
《生殖医学杂志》
CAS
2017年第1期29-33,共5页
Journal of Reproductive Medicine
