摘要
目的研究夏至草（Lagopsissupina）全草的化学成分。方法采用硅胶、SephadexLH-20柱色谱和半制备HPLC等色谱方法对夏至草化学成分进行分离和纯化，结合其理化性质及MS、NMR等谱学数据鉴定化合物的结构。结果从夏至草提取物正己烷、二氯甲烷、水萃取部位分离并鉴定了13个化合物，分别是叶绿醇（1）、胡萝卜苷（2）、8-O-乙酰哈巴苷（3）、antirrinoside（4）、筋骨草苷（5）、益母草苷A（6）、哈巴苷（7）、l-O-咖啡酰基β-D-吡喃葡萄糖（8）、1-O-对香豆酰基-β-D-葡萄糖（9）、2-hydroxy-5-（2-hydroxyethyl）phenyl-1—0-β-D—glucopyranoside（10）、methyl2-0-β—D-ducopyranosylbenzoate（11）、腺苷（12）和蔗糖（13）。结论化合物1，3～13为首次从夏至草属植物中分离得到。
OBJECTIVE To investigate the chemical constituents from the whole plants of Lagopsis supina. METHODS The compounds were isolated and purified by various column chromatography, and their structures were identified based on their physio- chemical properties and spectroscopic data. RESULTS Thirteen compounds were isolated from the n-hexane, dichloromethane, and water extracts of the whole plants of Lagopsis supina by using various chromatographic methods. Their structures were identified as phy- tol （ 1 ）, daucosterol （ 2）, 8-O-acetylharpagide （ 3 ）, antirrinoside （ 4 ）, ajugoside （ 5 ）, ajugol （ 6 ）, harpagide （ 7 ）, 1-O-caffeoyl-β-D- glucopyranose （ 8 ）, 1-O-coumaroyl-β-D-glucopyranose （ 9 ）, 2-hydroxy-5-（ 2-hydroxyethyl ） phenyl-l-O-β-D-glucopyranoside （ 10 ）, methyl 2-O-β-D-glucopyranosylbenzoate （ 11 ）, adenosine （ 12）, and sucrose （ 13 ）, respectively. CONCLUSION Compounds 1 and 3 - 13 are isolated from the plants of Lagopsis genus for the first time.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2016年第23期2005-2008,共4页
Chinese Pharmaceutical Journal
基金
国家"重大新药创制"科技重大专项资助项目(2013ZX09402201001)
教育部新世纪优秀人才支持计划资助项目(NCET-13-0693)
