摘要
目的研究益智Alpinia oxyphylla仁的化学成分。方法采用硅胶、MCI柱色谱、Sephadex LH-20、重结晶、半制备液相进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从益智仁95%乙醇提取物的醋酸乙酯部位分离并鉴定16个化合物,分别鉴定为邻苯二甲酸-双(2′-乙基庚基)酯(1)、(E)-1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)-hept-4-en-3-one(2)、5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone(3)、1β,4β,7β-trihydroxyeudesmane(4)、bullatantriol(5)、1,5-epoxy-3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptanes(6)、1-tetratriacontanol(7)、dihydrogingerenone B(8)、杨芽黄素(9)、白杨素(10)、oxyphyllenone B(11)、(1R,4R,10R)-1β,4α-dihydroxy-11,12,13-trinor-5,6-eudesmen-7-one(12)、胡萝卜苷(13)、1-(4′-羟基苯基)-7-(3″-甲氧基-4″-羟基苯基)-4-烯-3-庚酮(14)、益智酮甲(15)、5-dehydroxy-hexahydro-demethoxycurcumin B(16)。结论其中化合物1、2、4~8为首次从该属植物中分离得到,化合物3为首次从该植物中分离得到。
Objective To study the chemical constituents of Alpinia oxyphylla. Methods The ethyl acetate fraction of 95% ethanol extract from A. oxphylla was isolated and purified by silica, MCI, Sephadex LH-20 and semi-preparative HPLC, then the structures of obtained compounds were identified by physicochemical properties and spectral data. Results Sixteen compounds were isolated and their chemical structures were identified as phthalic acid-bis(2′-ethyl heptanyl) easter(1),(E)-1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxy-phenyl)-hept-4-en-3-one(2), 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone(3), 1β,4β,7β-trihydroxyeudesmane(4), bullatantriol(5), 1,5-epoxy-3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptanes(6), 1-tetratriacontanol(7), dihydrogingerenone B(8), tectochrysin(9), chrysin(10), oxyphyllenone B(11),(1 R,4 R,10 R)-1β,4α-dihydroxy-11,12,13-trinor-5,6-eudesmen-7-one(12), daucosterol(13), 1-(4′-hydroxyphenyl)-7-(3″-methoxy-4″-hydroxyphenyl)-4-ene-3-heptanone(14), yakuchinone A(15) and 5-dehydroxy-hexahydro-demethoxycurcumin B(16). Conclusion A total of 16 compounds were isolated and identified. The compounds 1—2, 4—8 are isolated from the genus for the first time, and compounds 3 were isolated from the plant for the first time.
作者
侯蕾
王亚玲
王文锦
李小霞
李田田
孙志勇
潘成学
HOU Lei;WANG Ya-ling;WANG Wen-jin;LI Xiao-xia;LI Tian-tian;SUN Zhi-yong;PAN Cheng-xue(Department of Pharmacy,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;College of Pharmacy,Zhengzhou University,Zhengzhou 450001,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第2期315-320,共6页
Chinese Traditional and Herbal Drugs
基金
郑州大学第一附属医院青年基金(2015S-02).
