摘要
目的探讨CA125与慢性心力衰竭的关系,同时探讨其与BNP、LVEF有无关联性。方法选取在我院心内科住院的120例慢性心力衰竭患者作为病例组,并依据NYHA分级标准,进一步将病例组分为Ⅰ-Ⅱ级组、Ⅲ级组及Ⅳ级组;同期选取100例健康体检者作为对照组,采用酶联免疫吸附法(ELISA)分别测定各组血清CA125、BNP水平,采用B超测定各组LVEF数值。结果:(1)心力衰竭组CA125数值为130.15±63.12U/ml显著高于对照组25.67±6.46U/ml(P<0.05);心力衰竭组BNP数值为458.12±200.46 ng/L显著高于对照组63.41±40.66 ng/L(P<0.05);心力衰竭组LVEF为45.65±7.33%显著低于对照组64.23±5.35%(P<0.05)。(2)NYHA Ⅰ-Ⅱ组BNP、CA125均显著低于NYHA Ⅲ组及IV组(P<0.05);NYHA Ⅲ组BNP、CA125显著低于NYHA IV组(P<0.05);NYHA Ⅰ-Ⅱ组LVEF高于NYHA Ⅲ组,两组间比较差异无统计学意义(P>0.05);NYHA Ⅰ-Ⅱ组LVEF显著高于NYHA IV组(P<0.05);NYHA Ⅲ组LVEF显著高于NYHA IV组(P<0.05)。(3)CA125与BNP存在正相关性(P<0.05),与LVEF存在负相关性(P<0.05)。结论 (1)CA125可能参与了慢性心力衰竭的发生、发展,对于慢性心力衰竭诊断、治疗可能有一定的价值。(2)CA125与BNP、LVEF可能存在相关性。
Objective： To explore the relationship between CA125 and chronic heart failure. At the same time, we discuss it with the BNP, LVEF presence of relevance. Methods： We select 120 eases patients with chronic heart failure in our heart of the hospital as the ease group. According to NYHA classification standard, further eases can be divided into grade I - II group, the level III and IV level group. We select 100 cases of healthy physical examination for the same period as the control group. We respect each serum CA125, BNP levels by using enzyme-linked immunosorbent （ELISA）. Results： （1） CA125 values of heart failure group （130. 15 ±63.12 ）U/ml are obviously higher than the control group （25. 67± 6.46 ） U/ml （ P 〈 0. 05 ）. BNP values of heart failure group （458. 12± 200. 46 ） ng/L are obviously higher than the control group （63.41 ±40. 66） ng/L（P 〈0.05）. LVEF of heart failure group（45.65±7.33% ）are obviously lower than the con- trol group（64. 23 ±5.35% ） （P 〈0. 05）. （2） NYHA I-II group BNP, CA125 were significantly lower than group NYHA III and IV group （P 〈0. 05）. NYHA III group BNP, CA125 significantly lower NYHA IV group （P 〈0.05）. NYHA III group LVEF higher than NYHA III group, the difference between the two groups was not statistically significant （ P 〉 0. 05 ）. NY- HA III group LVEF was significantly higher NYHA IV group （ P 〈 0.05） ; NYHA III group LVEF was significantly higher NYHA IV group （P 〈 0.05 ）. （3） CA125 and BNP was positively correlated （P 〈 0.05 ）, and there is a negative correla- tion with LVEF （P 〈 0.05 ）. Conclusion ： （ 1 ） CA125 may be involved in chronic heart failure, the development of chronic heart failure diagnosis, treatment may have some value. （2）There is possible correlation between CA125 and BNP, LVEF.
出处
《泰山医学院学报》
CAS
2016年第8期860-862,共3页
Journal of Taishan Medical College
