摘要
目的探讨血清癌抗原（CA）125在胸腔积液中的检测价值。方法选取2010年1月2012年9月来我院就诊的胸腔积液患者128例，测定血清CAl25浓度，对比不同性别、胸水性质、胸水量及胸水部位患者血清CA125阳性率及水平的差异；比较恶性胸腔积液患者与结核性、炎性、漏出性胸腔积液患者间上述指标的差异；对血清CAl25浓度与胸水深度进行相关分析。结果恶性及良性胸腔积液患者的血清CA125阳性率分别为83．3％（35／42）和76．7％（66／88），差异无统计学意义（x2=0．74，P〉0．05）；恶性胸腔积液患者的血清CA125（177．8±31．4）U／ml显著高于良性胸腔积液（110．6±13．6）U／ml，差异有统计学意义（t=31．24，P〈0．05）；恶性胸腔积液血清CA125（177．8±31．4）U／ml高于炎性胸腔积液（72．5±12．8）U／ml（P〈0．05），但与结核性（140．6±28．2）U／ml、漏出性胸腔积液（154．3±30．5）U／ml比较差异无统计学意义（P〉0．05）；结核性、炎性、漏出性积液与恶性胸腔积液血清CA125阳性率差异无统计学意义[75．8％（25／33）、70．O％（20／29）、87．5％（21／24）与83．3％（35／42），X2=3．48，P〉0．05]；少量、中量、大量胸腔积液患者的血清CA125浓度依次升高[（56．4±18．2）、（120．2±24．5）、（185．5±34．6）U／m1]，各组间比较差异有统计学意义（F=296．03，P〈0．05）；血清CA125浓度与胸水深度呈正相关（r=0．56，P〈0．01）；不同性别、胸水部位患者血清CA125阳性率及水平差异均无统计学意义（P均〉0．05）。结论不论是良性还是恶性胸腔积液，血清CA125均明显升高，血清CA125阳性对判断胸水良恶性的意义不大；血清CA125浓度与胸水深度呈正相关，可以作为监测胸水量变化的参考指标。
Objective To investigate the change of serum cancer antigen （CA） 125 in patients with pleural effusion. Methods One hundred and twenty-eight patients with pleural effusion were admitted to the Naval General Hospital of People＇s Liberation Army from January 2010 to September 2012 were selected as our subjects. The level of serum CA125 was measured. The difference of serum CA125 positive rate and level were compared according to gender, pleural effusion nature, quantity and pleura] effusion chest area; And the difference of patients with malignant pleural effusion tuberculosis, inflammatory, exudative pleural effusion based on above indicators. The correlation between serum CA125 level and pleural effusion depth were analyzed. Results The positive proportions of CA125 were 83.3% （35/42） and 76. 7 % （66/88） of patients with malignant and benign effusion respectively, and there was no significant difference（ X2 = 0. 74, P 〉 0.05 ）. The serum CA125 level of patients with malignant pleural effusion was significantly higher than benign ones （ （ 177.8 ±31.4） U/ml vs. （ 110. 6 ± 13.6） U/ml,t =31.24,P 〈0.05）. There were no significant difference in the positive proportion of serum CA125 between malignant, tuberculous, inflammatory and transudative pleural effusion（75.8% （25/33） ,70. 0% （20/29） ,87. 5% （21/24） and 83.3% （35/42） ,P 〉 0. 05 ）. Serum CA125 levels of patients with malignant pleural effusion were significantly higher than that with inflammatory （ （ 177. 8 ± 31.4） U/ml vs. （72. 5± 12. 8 ） U/ml, P 〈 0. 05 ）, but the differences were not significant among malignant, tuberculous and transudative pleural effusion group （ （140. 6 ±28.2 ） U/ml, （154. 3 ± 30. 5 ） U/ml, P 〉 0. 05 ）. The serum CA125 levels of patients with small , moderate and large effusions were （ 56. 4± 18.2 ） U/ml, （ 120. 2 ± 24. 5 ） U/ml and （ 185.5 ± 34. 6 ） U/ml respectively, and the difference among these groups were significant（ F =296. 03 ,
出处
《中国综合临床》
2013年第12期1281-1284,共4页
Clinical Medicine of China
关键词
胸腔积液
癌抗原125
血清
Pleural effusion
Cancer antigen 125
Serum
