摘要
目的分析血清糖类抗原125(CA125)、心肌肌钙蛋白I(cTnI)水平与扩张型心肌病(DCM)并慢性充血性心力衰竭(CHF)患者心功能的相关性。方法选取2015年2月—2016年2月广西壮族自治区来宾市中医医院收治的DCM并CHF患者98例作为A组,选取同期收治的单纯DCM患者96例作为B组,另选取同期体检健康者96例作为对照组;参照美国纽约心脏病协会(NYHA)心功能分级标准将DCM并CHF患者分为Ⅰ级22例、Ⅱ级24例、Ⅲ级25例、Ⅳ级27例。比较3组受试者及不同心功能分级DCM并CHF患者血清CA125、cTnI水平,并分析血清CA125、cTnI水平与DCM并CHF患者心功能分级的相关性。结果 A组和B组患者血清CA125、cTnI水平高于对照组,A组患者血清CA125、cTnI水平高于B组(P<0.05)。心功能分级Ⅱ级、Ⅲ级、Ⅳ级患者血清CA125、cTnI水平高于Ⅰ级患者,Ⅲ级、Ⅳ级患者血清CA125、cTnI水平高于Ⅱ级患者,Ⅳ级患者血清CA125、cTnI水平高于Ⅲ级患者(P<0.05)。Spearman秩相关性分析结果显示,血清CA125、cTnI水平与心功能分级呈正相关(rs分别为0.829、0.453,P<0.05)。结论血清CA125、cTnI水平与DCM并CHF患者心功能分级呈正相关。
Objective To analyze the correlations between serum level of CA125,of cTnI and cardiac function of dilated cardiomyopathy patients complicated with chronic congestive heart failure. Methods From February 2015 to February2016 in the Traditional Chinese Medicine Hospital of Laibin,98 dilated cardiomyopathy patients complicated with chronic congestive heart failure were selected as A group,96 dilated cardiomyopathy patients did not complicate with chronic congestive heart failure were selected as B group,meanwhile 96 healthy individuals admitted to this hospital for physical examination were selected as control group; according to NYHA cardiac function grading standard, patients of A group were divided into four subgroups： A1 group（ with Ⅰ- grade NYHA grading,n = 22）,A2 group（ with Ⅱ- grade NYHA grading,n = 24）,A3group（ with Ⅲ- grade NYHA grading,n = 25） and A4 group（ with Ⅳ- grade NYHA grading,n = 27）. Serum levels of CA125 and cTnI were compared among the three groups and the four subgroups,meanwhile correlations between serum level of CA125,of cTnI and cardiac function of dilated cardiomyopathy patients complicated with chronic congestive heart failure were analyzed. Results Serum levels of CA125 and cTnI of A group and B group were statistically significantly higher than those of control group,meanwhile serum levels of CA125 and cTnI of A group were statistically significantly higher than those of B group（ P 〈 0. 05）. Serum levels of CA125 and cTnI of A2 group,A3 group and A4 group were statistically significantly higher than those of A1 group,serum levels of CA125 and cTnI of A3 group and A4 group were statistically significantly higher than those of A2 group,meanwhile serum levels of CA125 and cTnI of A4 group were statistically significantly higher than those of A3 group（ P 〈 0. 05）. Spearman rank correlation analysis results showed that,serum levels of CA125 and cTnI was positively correlated with cardiac function grading,respectively（ rs= 0. 829,0. 453; P 〈 0. 05）
出处
《实用心脑肺血管病杂志》
2017年第1期18-21,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
