摘要
目的:探讨急性心力衰竭患者血浆N末端B型利钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)、肌钙蛋白Ⅰ(cTnⅠ)和糖类抗原125(CA125)与心功能的相关性。方法:选择杭州市大江东医院2017年5月至2019年5月收治的急性心力衰竭患者97例为观察组,根据纽约心脏病协会(NYHA)心功能分级,Ⅱ级组29例,Ⅲ级组51例,Ⅳ级组17例;另选择该院2017年5月至2019年5月健康体检者50例为对照组。比较两组血浆NT-proBNP、hs-CRP、cTnⅠ和CA125水平变化及心功能指标[左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)]变化;比较不同心功能分级组血浆NT-proBNP、hs-CRP、cTnⅠ和CA125水平变化及LVEDD和LVEF变化;分析NT-proBNP、hs-CRP、cTnⅠ和CA125与LVEDD和LVEF相关性。结果:观察组血浆NT-proBNP[(5 684.21±174.39)ng/L]、hs-CRP[(16.54±3.27)mg/L]、cTnⅠ[(0.43±0.13)μg/L]和CA125[(83.24±15.46)U/mL]均高于对照组( t=216.813、25.684、19.432、34.138,均 P<0.05)。观察组LVEDD[(63.21±4.87)mm]高于对照组[(48.97±2.41)mm],而LVEF[(39.27±3.25)%]低于对照组[(62.87±4.36)%]( t=19.461、37.008,均 P<0.05)。Ⅳ级组血浆NT-proBNP[(7 368.18±201.05)ng/L]、hs-CRP[(24.19±4.18)mg/L]、cTnⅠ[(0.63±0.14)μg/L]和CA125[(164.52±27.48)U/mL]均高于Ⅱ级组和Ⅲ级组(Ⅲ级组: t=31.109、6.557、5.321、13.017,Ⅱ级组: t=75.873、16.582、11.755、23.178,均 P<0.05);Ⅲ级组血浆NT-proBNP[(5 751.42±180.34)ng/L]、hs-CRP[(15.98±4.56)mg/L]、cTnⅠ[(0.41±0.15)μg/L]和CA125[(87.97±18.45)U/mL]均高于Ⅱ级组[(3481.34±145.26)ng/L、(8.23±2.37)mg/L、(0.25±0.08)μg/L和(28.43±12.21)U/mL]( t=57.893、8.507、5.320、15.530,均 P<0.05)。Ⅳ级组LVEDD[(67.95±5.15)mm]高于Ⅱ级组和Ⅲ级组(Ⅲ级组: t=3.553,Ⅱ级组: t=8.157,均 P<0.05),而LVEF[(34.28±2.36)%]低于Ⅱ级组和Ⅲ级组(Ⅲ级组: t=6.673,Ⅱ级组: t=10.417,均 P<0.05);Ⅲ级组LVEDD[(62.78±5.21)mm]高于Ⅱ级组[(57.87±3.25)mm]( t=4.586, P<0.05),而LVEF[(39.98±3.24)%]低于Ⅱ级组[(45.
Objective To investigate the relationship between plasma N-terminal B-type natriuretic peptide precursor(NT-proBNP),hypersensitive C-reactive protein(hs-CRP),troponinⅠ(cTnⅠ)and carbohydrate antigen 125(CA125)and cardiac function in patients with acute heart failure.Methods From May 2017 to May 2019,97 patients with acute heart failure admitted to Hangzhou Dajiangdong Hospital were selected as the observation group.According to the cardiac function classification of New York Heart Association(NYHA),29 patients were classified as gradeⅡgroup,51 patients as gradeⅢgroup and 17 patients as gradeⅣgroup.Fifty healthy people were selected as control group.The changes of plasma NT-proBNP,hs-CRP,cTnⅠand CA125 levels,left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)were compared between the two groups.The changes of plasma NT-proBNP,hs-CRP,cTnⅠand CA125 levels,as well as the changes of LVED and LVEF in the different heart function grading group were compared.The correlation between plasma NT-proBNP,hs-CRP,cTnⅠ,CA125 and LVEDD,LVEF was analyzed.Results The plasma NT-proBNP[(5684.21±174.39)ng/L],hs-CRP[(16.54±3.27)mg/L],cTnⅠ[(0.43±0.13)g/L]and CA125[(83.24±15.46)U/mL]in the observation group were higher than those in the control group(t=216.813,25.684,19.432,34.138,all P<0.05).The LVEDD in the observation group[(63.21±4.87)mm]was higher than that in the control group[(48.97±2.41)mm],and the LVEFin the observation group[(39.27±3.25)%]was lower than that in the control group[(62.87±4.36)%],the differences were statistically significant(t=19.461,37.008,all P<0.05).The levels of NT-proBNP[(7368.18±201.05)ng/L],hs-CRP[(24.19±4.18)mg/L],cTnⅠ[(0.63±0.14)μg/L]and CA125[(164.52±27.48)U/mL]in the gradeⅣgroup were higher than those in the gradeⅡgroup and gradeⅢgroup(gradeⅢgroup:t=31.109,6.557,5.321,13.017;gradeⅡgroup:t=75.873,16.582,11.755,23.178,all P<0.05).The plasma NT-proBNP[(5751.42±180.34)ng/L],hs-CRP[(15.98±4.56)mg/L],cTnⅠ[(0.41±0.15)g/L]and
作者
陈金焕
张义林
Chen Jinhuan;Zhang Yilin(Department of Cardiovascular Medicine,Dajiangdong Hospital,Hangzhou,Zhejiang 311225,China)
出处
《中国基层医药》
CAS
2020年第7期808-812,共5页
Chinese Journal of Primary Medicine and Pharmacy
