摘要
目的分析沙库巴曲缬沙坦与抗心衰联合治疗对射血分数降低心力衰竭(HFrEF)患者心功能分级、6min步行试验及心脏射血分数(LVEF)的影响。方法选择2019年12月至2021年10月诊治的HFrEF患者82例,采用计算机随机数分组法将全部患者分成标准组和联合组,例数均41例。标准组患者使用抗心衰药物治疗。联合组患者使用沙库巴曲缬沙坦与抗心衰联合治疗。对比分析两组患者心功能分级、6min步行试验及LVEF、心肌损伤指标水平。结果治疗结束1d,2组患者心功能分级差异比较有统计学意义(P<0.05)。治疗前1d,2组患者6min步行试验距离及LVEF值差异比较无统计学意义(P>0.05)。治疗结束1d,联合组患者6min步行试验距离及LVEF值高于标准组(P<0.05)。治疗前1d,2组患者NT-proBNP、I cTnI水平差异比较无统计学意义(P>0.05)。治疗结束1d,联合组患者NT-proBNP、I cTnI水平低于标准组(P<0.05)。结论沙库巴曲缬沙坦与抗心衰联合治疗对HFrEF能明显患者心功能分级,增加6min步行试验距离及心脏射血分数,建议使用。
Objective To analyze the effect of sakubatril valsartan in combination with standard heart failure therapy on cardiac function classification,6-min walking test and left ventricular ejection fraction(LVEF)in patients with heart failure with reduced ejection fraction(HFrEF).Methods Eighty-two patients with HFrEF in our hospital from December 2019 to October 2021 were enrolled,and randomly classified into two groups by computer,each with 41 cases.Standard group received standard heart failure therapy,while combined group received sakubatril valsartan in combination with standard heart failure therapy.Then the cardiac function classification,6-min walking test,LVEF and myocardial injury markers were compared between two groups.Results The cardiac function classification at post-treatment 1 d yielded statistical difference between two groups(P<0.05).The 6-min walking distance and LVEF value at the baseline demonstrated no statistical difference between groups(P>0.05),while the two values at post-treatment 1 d of combined group were remarkably higher in combined group than in standard group(P<0.05).Serum N-terminal prohormone of brain natriuretic peptide(NTproBNP)and cardiac troponin I(cTnI)levels at baseline denoted no significant difference between groups(P>0.05),while the levels of two serum indicators were obviously lower in combined group than in standard group at post-treatment 1 d(P<0.05).Conclusion Application of sakubatril valsartan in combination with standard heart failure therapy in the treatment of HFrEF can effectively improve the cardiac function,improve the 6-min walking distance and LVEF value in patients,which is worthy of recommendation.
作者
宋戈
何兆辉
韩慧想
Song Ge;He Zhaohui;Han Huixiang(The First Afiliated Hospital of Henan University,Kaifeng,Henan 475000)
出处
《辽宁医学杂志》
2024年第4期26-28,共3页
Medical Journal of Liaoning
关键词
沙库巴曲缬沙坦
抗心衰
HFrEF
心功能分级
6min步行试验
心脏射血分数
S]acubitril Valsartan
Standard heart failure therapy
HFrEF
Cardiac function classification
The 6-min walking test
Left ventricular ejection fraction
