摘要
目的探讨慢性心力衰竭患者血清CA125、BNP水平变化及临床意义。方法选取2010年2月—2012年5月收治的86例慢性心力衰竭患者为研究对象,作为观察组。比较按NYHA分级的不同心功能级别患者的CA125、BNP水平的动态变化。同时以同期进行健康体检的健康者40例,作为对照组。比较两组患者间的CA125、BNP水平。结果观察组中各级心功能组患者CA125与BNP水平较对照组相比,均有显著增高,差异有显著性意义(P<0.05)。同时,Ⅲ级与Ⅳ级患者较Ⅱ级患者相比,CA125与BNP水平亦有明显增高。观察组患者心衰得到控制后,血清中CA125与BNP水平均显著降低,差异有统计学意义(P<0.05)。结论 CA125与BNP水平水平高低可作为判断慢性心力衰竭患者心功能严重程度的重要指标,两种指标联合检测有利于对心功能进行综合评价,并有效评判治疗效果。
Objective To investigate the clinical value of serum carbohydrate antigen 125 （CA125） and plasma BNP lev- els in patients with heart failure （HF）. Methods Totally 86 patients with HF who surgically treated in our hospital were included in this study form February 2010 to May 2012. Serum levels of CA125 and BNP were measured preoperatively and detected in different NYHA functional class. 40 healthy people were the control group. Compare of with the level of CA125and BNP between the two groups. Results The levels of CA125 and BNP in different NYHA functional class were increased after treatment. It was significantly higher than control group. While the level of CA125 and BNP was de- creased compared with before treatment, the differences were statistically significant （ P 〈 0.05 ）. Conclusion The el- evated levels of CA125 and BNP are predictive of the advanced stage of the tumor,they can be used as a laboratory mak- er to judge the disease severity and predict the progress of HF.
出处
《医药论坛杂志》
2013年第3期3-5,共3页
Journal of Medical Forum
