摘要
目的：探讨正常人肾脏磁共振体素内不相干运动成像（IVIM）和扩散峰度成像（DKI）的定量参数指标特点。方法：对27名健康志愿者行肾脏IVIM和DKI检查,通过后处理分析,获得双肾皮髓质IVIM相关参数ADC、Dfast、Dslow、fp以及DKI相关参数MD、MK的测量值。分析同一测量者前后2次测得数据的一致性,比较正常肾脏左右侧以及同侧肾脏不同部位IVIM、DKI各参数间的差异,比较正常肾脏皮质、髓质各参数均值间的差异。结果：IVIM序列的ADC值、Dslow值、fp值和DKI序列的MD值、MK值前后两次测量总体一致性较好,Dfast值一致性一般;IVIM、DKI各参数测量值在双侧肾脏间均没有统计学差异（P值为0.058~0.954）,同侧肾脏皮髓质不同部位各参数测量值间亦均没有统计学差异（P值为0.171~0.995）;正常肾脏皮质ADC值、Dslow值高于髓质（t=7.072,P〈0.05;t=10.057,P〈0.05）,皮髓质Dfast值、fp值差异不具有统计学意义（P〉0.05）;正常肾脏皮质MD值高于髓质（t=10.268,P〈0.05）,髓质MK值高于肾皮质（t=-10.228,P〈0.05）。结论：正常肾脏IVIM和DKI成像能显示皮髓质间差异,反映肾脏生理功能,提示在评估肾脏疾病具有潜在应用价值,整体检查结果具有一定稳定性。
Objective：To evaluate the characteristic parameters of intravoxel incoherent motion（IVIM）and diffusion kurtosis imaging（DKI）on normal kidney MRI.Methods：27healthy volunteers underwent IVIM and DKI MRI of kidneys using 1.5Tscanner.Maps of apparent diffusion coefficient（ADC）,pseudodiffusion coefficient（Dfast）,pure diffusion coefficient（Dslow）,perfusion fraction（fp）,mean diffusion（MD）,mean kurtosis（MK）were produced by image post processing.The IVIM and DKI parameters of renal cortex and medulla were measured.Intraclass correlation coefficient（ICC）test is adopted to check the consistency.The differences of upper,middle and lower poles were compared with analysis of variance（ANOVA）.The differences between left and right kidneys,between the cortex and medulla were compared with matchedpairs t-test.Results：Among the values of the same measurer at different time,ADC,Dslow,fp,MD and MK showed better measuring consistency in IVIM sequence,while Dfastshowed moderate measuring consistency.There were no statistically significant differences of all parameters between IVIM and DKI for measuing kidneys.ADC、Dslowvalues obtained in the cortex were significantly higher than those in the medulla（t=7.072,P〈0.05;t=10.057,P〈0.05）.There were no significant differences between the values of cortex and medulla in Dfastand fp（P〉0.05）.In DKI parametes,MD value of the medulla was lower than that of the cortex（t=10.268,P〈0.05）,whereas MK value of the medulla were higher than that of the cortex（t=-10.228,P〈0.05）.Conclusion：Some functional parameters of IVIM and DKI can reveal the difference between the cortex and medulla of the kidney,which can reflect the kidney function and provide potential value in the assessment of kidney disease.The measuring results of IVIM and DKI show good consistency.
出处
《放射学实践》
北大核心
2016年第10期908-913,共6页
Radiologic Practice
关键词
磁共振成像
肾
对比研究
Magnetic resonance imaging
Kidney
Comp study
