摘要
目的:对比分析常规MRI及DKI对肝豆状核变性疾病的诊断效能。方法:35例肝豆状核变性(HLD)患者及性别和年龄相匹配的30例健康志愿者(对照组),采用常规T2WI和DKI序列行3.0T MRI扫描,测量双侧豆状核和尾状核头部的平均扩散峰度(MK)、径向扩散峰度(RK)、轴向扩散峰度(AK)和T2信号变化率,采用校正t检验比较两组间各参数值的差异,采用ROC曲线分析各参数的诊断效能。结果:HLD组双侧豆状核的MK值及T2信号变化率(0.956±0.105、0.308±0.210)均高于对照组(0.832±0.086、0.641±0.473),差异具有统计学意义(P<0.05),两组间KA值及KR值的差异无统计学意义;HLD组双侧尾状核头部的MK、KA、KR值及T2信号变化率(0.691±0.123、0.825±0.124、0.597±0.175、0.602±0.440)均高于对照组(0.567±0.066、0.696±0.080、0.497±0.079、0.326±0.225),差异具有统计学意义(P<0.05)。ROC曲线分析结果显示,双侧豆状核的MK值和T2信号变化率的曲线下面积(AUC)分别为0.825和0.708(P<0.05),双侧尾状核头部的MK、KR和KA值及T2信号变化率的曲线下面积分别为0.814、0.822、0.670和0.686(P<0.05)。结论:DKI技术对显示大脑微观结构的变化较常规MRI序列的敏感性和特异性更高,更有利于肝豆状核变性疾病的诊断。
Objective:To evaluate the sensitivity and specificity of diffusion kurtosis imaging(DKI)for detecting hepatolenticular degeneration disease(HLD)and compared with conventional magnetic resonance imaging(MRI).Methods:A total of 35 HLD patients in our hospital were enrolled and 30 age-and sex-matched healthy volunteers were recruited as control group.The MRI examination was performed with conventional MR T 2-weighted sequence and DKI sequence using a 3.0-Tesla MR system.Thereafter,the data were analyzed with methods of manual ROI using program of ADW4.6,and DKI parameters including mean kurtosis(MK),radial kurtosis(RK)and axial kurtosis(AK),and T 2-signal intensity ratio were obtained.Results:Compared to healthy volunteers,MK and T 2-ratio of the lenticular nucleus(LN)in HLD group(0.956±0.105 and 0.308±0.210)were higher than those in control group(0.832±0.086 and 0.641±0.473),the difference was significant with P-values less than 0.05.MK,AK,RK and T 2-ratio of the bilateral head of caudate nucleus(HCN)in HLD group(0.691±0.123,0.825±0.124,0.597±0.175,0.602±0.440)were all higher than those in control group(0.567±0.066,0.696±0.080,0.497±0.079,0.326±0.225),the differences were significant with P-values less than 0.05.The area under ROC curve(AUC)of MK,T 2-ratio in LN was 0.825 and 0.708,respectively.The AUC of MK,AK,RK and T 2-ratio in HCN was 0.814,0.822,0.670 and 0.686 respectively.The differences were significant with P-values less than 0.05 for all DKI indexes.Conclusion:The technique of DKI provides higher sensitivity and specificity than conventional MRI to detect the changes of brian microstructure,it may provide effective value for diagosis.
作者
卢琦
王安琴
张春芸
武红利
徐春生
LU Qi;WANG An-qin;ZHANG Chun-yun(he First Affiliated Hospital of Anhui University of Chinese Medicine,Image Center,Hefei 230031,China)
出处
《放射学实践》
北大核心
2018年第4期369-372,共4页
Radiologic Practice
基金
国家重点基础研究973发展计划(2010CB530500)
国家自然科学基金项目(81202768)
安徽中医学院青年科学临床基金(2011qn022)
关键词
扩散峰度成像
磁共振成像
脑部疾病
肝豆状核变性
基底核
Diffusion kurtosis imaging
Magnetic resonance imaging
Brain diseases
Hepatolenticular degeneration
Basal nucleus
