摘要
目的观察芪龙通络胶囊对动脉硬化性脑梗死病人血管内皮功能的影响及临床治疗作用。方法 150例病人随机分为治疗组、安慰剂组和对照组,每组50例。对照组应用阿司匹林、氯吡格雷等抗血小板聚集药物,卡托普利等降压药物,硝酸异山梨酯等硝酸酯类药物等治疗,并加服银杏叶胶囊模拟剂和芪龙通络胶囊模拟剂;安慰剂组在对照组基础上加服银杏叶胶囊和芪龙通络胶囊模拟剂;治疗组在对照组基础上加服芪龙通络胶囊和银杏叶胶囊模拟剂。观察3组治疗前后血清血管内皮生长因子(VEGF)、一氧化氮(NO)、超氧化物歧化酶(SOD)、美国国立卫生研究院率中量表(NIHSS)评分、中医症候积分的变化。结果治疗前3组VEGF,NO,SOD,NIHSS评分、中医症候积分差异无统计学意义(P>0.05)。治疗8周后治疗组、安慰剂组比对照组血清VEGF,NO,SOD表达水平明显升高(P<0.05),NIHSS评分、中医症候积分明显降低(P<0.05);治疗组比安慰剂组血清VEGF,NO,SOD表达水平明显升高(P<0.05),NIHSS评分、中医症候积分明显降低(P<0.05)。3组总有效率比较,治疗组、安慰剂组总有效率明显高于对照组(82.0%,58.0%vs 34.0%P<0.05),治疗组总有效率明显高于安慰剂组(P<0.05)。结论芪龙通络胶囊能明显改善动脉硬化性脑梗死病人血管内皮功能,降低NIHSS评分及中医症候积分,改善临床症状。
Objective To observe the effect of Qilong Tongluo capsule（QTC）in the treatment of patients with atherosclerotic cerebral infarction.Methods One hundred and fifty patients with atherosclerotic cerebral infarction were randomly divided into treatment group,the placebo group and the control group,each group were 50 cases.The patients of control group were given such as aspirin,clopidogrel etc,such as captopril antihypertensive medications,such as those of nitrate medications,such as different yamanashi nitrate ester drug therapy,and add ginkgo biloba capsules agent and stilbene dragon know luo capsule simulation agent.The patients of Placebo group were given the standard treatment and Ginkgo biloba capsules agent and QTC simulation agent.The patients of treatment group were given the standard treatment and Qilong Tongluo capsule and gingko leaf capsule simulation agent.To observe the expression of vascular endothelial growth factor（VEGF）,nitric oxide（NO）,superoxide dismutase（SOD）,National Institutes of Health Stroke Scale（NIHSS）score,traditional Chinese medicine（TCM）symptom integral before and after 8 weeks of treatment.Results There were no difference in VEGF,NO,SOD,NIHSS score TCM symptom integral among three groups（P〉0.05）.After 12 weeks of treatment,the treatment and placebo group compared with the control group,the serum levels of VEGF,NO,SOD were increasd（P〈0.05）,NIHSS score and traditional Chinese medicine symptom integral were decreasd（P〈0.05）.The treatment compared with placebo group,the serum levels of VEGF,NO,SOD were increasd（P〈0.05）,NIHSS score and traditional Chinese medicine symptom integral were decreasd（P〈0.05）.Compared total effective rate of the three groups,it was higher in the treatment and placebo group than the control group（P〈0.05）,it was higher in treatment group than the placebo group（P〈0.05）.Conclusion QTC can improve vascular endothelial fuction,decrease NIHSS score and TCM symptom integral in patients with atherosclerotic
出处
《中西医结合心脑血管病杂志》
2016年第18期2104-2106,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
动脉硬化性脑梗死
芪龙通络胶囊
血管内皮功能
NIHSS评分
atherosclerotic cerebral infarction
Qilong Tongluo capsule
vascular endothelial fuction
National Institutes of Health Stroke Scale score
