摘要
目的分析支气管哮喘（简称哮喘）患者血清瘦素水平的影响因素。方法前瞻性、连续入组从2014年4月至2015年12月在北京大学第三医院呼吸内科门诊就诊的哮喘患者78例（哮喘组），同期健康体检者29名（对照组）。通过酶联免疫吸附（ELISA）法测定血清瘦素水平。记录哮喘组患者性别、体质指数（BMI）、起病年龄、过敏原检测结果、诱导痰细胞计数及分类、肺功能及哮喘控制水平等，根据上述因素分别对哮喘组进行亚分组，比较不同组间血清瘦素水平的差异。结果哮喘组与对照组的血清瘦素水平差异无统计学意义[（15.0±10.4）比（15.2±11.7）μg/L，P＝0.939]。女性哮喘患者血清瘦素水平显著高于男性[（18.2±10.7）比（7.9±4.8）μg/L，P〈0.001]；肥胖的哮喘患者血清瘦素水平显著高于超重患者、BMI正常患者、消瘦患者、对照组[（29.7±10.8）比（17.1±11.1）、（11.8±7.7）、（9.1±0.96）、（15.2±11.7）μg/L]（均P〈0.01）。女性哮喘患者血清瘦素水平与诱导痰嗜酸粒细胞百分数呈正相关（r＝0.331，P＝0.032）。起病年龄、过敏原检测阳性、是否存在气流受限、哮喘控制水平等不影响血清瘦素水平。结论性别和BMI是影响哮喘患者血清瘦素水平的重要因素。
Objective To analysis the correlative factors that probably affect serum leptin levels in asthmatic patients. Methods Seventy-eight patients with asthma and 29 health controls who were admitted into outpatient clinic of Peking University Third Hospital from April 2014 to December 2015 were consecutively enrolled in our study prospectively. Serum leptin level was measured by enzyme-linked immunosorbent assay （ELISA）. The sex, body mass index （BMI）, onset age of asthma, allergen detection test, induced sputum cell count and classification, lung function test and asthma control level were recorded. Asthmatic patients were further divided into groups according to these factors and serum leptin levels were compared among groups. Results Serum leptin levels were not different between asthmatic patients and health controls [ （ 15.0 ± 10. 4 ） vs （ 15.2 ± 11.7 ） μg/L, P = 0. 939]. Female asthmatic patients had significantly higher serum leptin levels than male [ （ 18. 2 ± 10. 7 ） vs （ 7.9 ± 4. 8 ） μg/L, P 〈 0. 001]. Asthmatic patients with obesity had significantly higher serum leptin levels than asthmatic patients with overweight, with normal BMI, with underweight and health controls [ （29. 7 ± 10. 8） vs （ 17. 1 ± 11.1 ）, （ 11.8±7. 7）, （9. 1 ±0. 96）, （ 15.2 ± 11.7） μg/L, all P 〈0. 01]. Serum leptin level was positively related to percentage of induced sputum eosinophil in female asthmatic patients （r = 0. 331, P = 0. 032）. Onset age of asthma, positive allergen detection, airflow limitation or asthma control level did not affect serum leptin level. Conclusion Sex and BMI are important factors affecting serum leptin levels in patients with asthma.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2016年第36期2889-2892,共4页
National Medical Journal of China
基金
国家自然科学基金青年基金项目（81400017）
北京大学第三医院回国人员启动基金（Y77429-01）
