摘要
目的探讨SSRIs联用丁螺环酮对首发强迫障碍患者疗效及认知功能的影响。方法将60例首发强迫障碍(OCD)患者随机分成两组,研究组接受SSRIs和丁螺环酮治疗,对照组单用SSRIs治疗,治疗时间6个月。采用YaleBrown强迫量表(Y-BOCS)、中国修订版韦氏记忆测验(WMS-RC)、Stroop色词测验(SCWT)、连线测验(TMT)A和B、威斯康星卡片分类测验(WCST)评定疗效和认知功能。结果治疗后研究组Y-BOCS总分、强迫行为因子分低于对照组(P<0.05)。治疗后研究组WMS-RC的记忆商、瞬时记忆、短时记忆评分高于对照组(P<0.05),TMT时间少于对照组(P<0.05),研究组SCWT用时低于对照组(P<0.05)。治疗后研究组WCST错误应答数、持续错误数均少于对照组(P<0.05)。研究组治疗后的Y-BOCS总分、强迫观念因子分、强迫行为因子分均低于治疗前(P<0.05),WMS-RC的记忆商、瞬时记忆、短时记忆分均高于治疗前(P<0.05),TMT时间少于治疗前(P<0.05),SCWT的错误数及用时均低于治疗前(P<0.05),WCST的正确应答数多于治疗前,错误应答数、持续错误数均显著少于治疗前(P<0.05)。结论 SSRIs联合丁螺环酮可有效改善强迫障碍患者的临床症状和认知功能。
Objective To explore effects of selective serotonin reuptake inhibitors（ SSRIs） combined with buspirone to improve clinical symptoms and cognitive functions in patients with obsessive compulsive disorder（ OCD）. Methods A total of60 patients with OCD were randomly divided into study group treated with SSRIs combined with buspirone and control group treated with SSRIs for 6 month. They were assessed with Yale-Brown Obsessive Compulsive Scale（ Y-BOCS）,Chinese Revised Wechsler Memory Scale（ WMS-RC）,Stroop Color Word Test（ SCWT）,Trail Making Test（ TMT） and Modified Wisconsin Card Sorting Test（ M-WCST） before and after treatment. Results After treatment,the total score and factor score of compulsive behavior of Y-BOCS in study group were all significantly lower than those in control group（ P〈0. 05）. After treatment,the scores of memory quotient,instantaneous memory and short-term memory of WMS-RC in study group were all significantly higher than those in control group（ P〈0. 05）; the time of TMT in study group was significantly less than that in control group（ P〈0. 05）,and the time of SCWT in study group was significantly less than that in control group（ P〈0. 05）. After treatment,the error responses and persistent error number of WCST in study group were significantly less than those in control group（ P〈0. 05）; the total score and factor scores of obsessive thought, compulsive behavior of Y-BOCS in study group were all significantly lower than those before treatment（ P〈0. 05）. In study group,the factor scores of memory quotient,instantaneous memory and short-term memory of WMS-RC after treatment were all significantly higher than those before treatment（ P〈0. 05）;the time of TMT after treatment was significantly less than that before treatment（ P〈0. 05）. In study group,the error numbers and time of SCWT after treatment were significantly less than those before treatment（ P〈0. 05）. In study group,the correct responses of WCST after treatment
出处
《精神医学杂志》
2016年第4期280-283,共4页
Journal of Psychiatry
关键词
选择性五羟色胺再摄取抑制剂
丁螺环酮
强迫障碍
认知功能
Selective serotonin reuptake inhibitors
Buspirone
Obsessive compulsive disorder
Cognitive function
