摘要
目的:分析氟西汀联合喹硫平治疗伴有强迫症状的精神分裂症患者的临床疗效。方法:纳入2019年1月—2020年8月间收治的伴有强迫症状的精神分裂症患者54例作为研究观察对象,基线分组采用系统抽样法,分成对照组27例与观察组27例,对照组给予喹硫平治疗,观察组给予氟西汀联合喹硫平治疗,评估两组患者治疗前后的Y-BOCS与BPRS评分,同时评价两组患者治疗前后的生活质量状况,比较治疗有效性。结果:对比观察组(26.03±6.45)分、(85.60±20.71)分与对照组治疗前的Y-BOCS评分(25.97±6.48)分与BPRS评分(85.31±19.87)分,t值分别是0.034、0.053,提示差异不高(P>0.05);对比观察组(18.45±4.53)分、(70.34±8.57)分与对照组治疗后的Y-BOCS评分(22.21±8.43)分与BPRS评分(77.08±10.46)分,提示前者优于后者,t值分别是2.042、2.590,差异有统计学意义(P<0.05);观察组临床有效率是92.59%(25/27),与对照组数据70.37%(19/27)相比,明显更高,差异显著(χ^(2)=4.418,P<0.05);观察组患者治疗前的生活质量评分(37.98±6.35)分较对照组(38.56±6.74)分并不存在统计学差异,t值是0.325(P>0.05),而在治疗后,观察组患者的生活质量评分(58.34±3.26)分显著高于对照组(49.56±4.02)分,t值是8.815,差异有统计学意义(P<0.05)。结论:针对伴有强迫症状的精神分裂症患者,临床给予氟西汀联合喹硫平治疗的效果是非常确切的,能够有效改善患者精神病性与强迫症状严重程度,进一步提高患者的生活质量,保证较高的临床疗效,在临床治疗中应当广泛推广。
Objective:To analyze the clinical efficacy of fluoxetine combined with quetiapine in the treatment of schizophrenia with obsessive-compulsive symptoms.Methods:Fifty-four schizophrenic patients with obsessivecompulsive symptoms admitted to our hospital from January 2019 to August 2020 were studied and observed.The baseline group was divided into control group(27 cases)and observation group(27 cases).The control group was treated with quetiapine and the observation group was treated with fluoxetine+quetiapine.The scores of Y-BOCS and BPRS before and after treatment were evaluated,and the quality of life of the two groups before and after treatment was also evaluated.Results:Compared with the observation group(26.03±6.45)and(85.60±20.71),the control group’s Y-BOCS score(25.97±6.48)and BPRS score(85.31±19.87)before treatment,the T values were 0.034,0.053,respectively Comparing the observation group(18.45±4.53)and(70.34±8.57)with the control group’s Y-BOCS score(22.21±8.43)and BPRS score(77.08±10.46)after treatment,it suggests that the former is superior to the latter,with T values of 2.042 and 2.590 respectively The clinical effective rate of the observation group was 92.59%(25/27),which was significantly higher than that of the control group(70.37%,19/27),with significant difference(χ^(2)=4.418,P<0.05).The quality of life score of the observation group before treatment(37.98±6.35)was not significantly different from that of the control group(38.56±6.74),and the T value was 0.325(P>0.05).After treatment,the quality of life score of the observation group(58.34±3.26)was significantly higher than that of the control group(49.56).Conclusion:For schizophrenia patients with obsessive-compulsive symptoms,the clinical effect of fluoxetine combined with quetiapine is very accurate,which can effectively improve the severity of psychotic and obsessive-compulsive symptoms,further improve the quality of life of patients,and ensure high clinical efficacy,and should be widely promoted in clinical treatment.
作者
王博
耿英华
WANG Bo;GENG Ying-hua(Department of Psychiatry,Fuxin Psychiatric Hospital,Liaoning Fuxin 123000,China)
出处
《中国药物滥用防治杂志》
CAS
2021年第1期67-70,76,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
氟西汀
喹硫平
强迫症状
精神分裂症
临床有效性
fluoxetine
quetiapine
obsessive symptoms
schizophrenia
clinical effectiveness
