摘要
目的 调查2006年我国10省市抑郁障碍患者药物治疗现况.方法 按照经济发展水平进行分层和方便取样方法,选择10省市41所精神疾病专科医院或综合医院精神科的1354例抑郁障碍门诊和住院患者,于2006年5月22-28日使用自制修订的调查问卷进行调查.结果 （1）1354例患者中,门诊患者921例（68.0%）,住院患者433例（32.0%）;男473例（34.9%）,女873例（64.5%）,缺失8例（0.6%）.（2）1281例（94.6%）患者接受抗抑郁药治疗,其中798例（62.3%）患者使用选择性5-HT再摄取抑制剂（SSRIs）治疗,以单一治疗为主（792例,99.2%）,使用频率前7位的药物依次为：帕罗西汀312例（24.4%）,氟西汀260例（20.3%）,文拉法辛250例（19.5%）,西酞普兰141例（11.0%）,舍曲林81例（6.3%）、米氮平53例（4.1%）;219例（17.1%）患者使用三环类药物治疗.（3）590例（43.6%）患者使用苯二氮革类药物治疗,281例（20.8%）患者使用抗精神病药,88例（6.5%）患者使用心境稳定剂;住院患者合并苯二氮革类药物的比例显著高于门诊患者（P＜0.05）,急性治疗期合并苯二氮革类药物的比例显著高于稳定治疗期（P＜0.01）.结论 新型抗抑郁药已经成为我国治疗抑郁障碍的主要药物,反映出目前抗抑郁药的发展趋势及抑郁障碍治疗理念的更新.
Objective To uncover the antidepressants drug use patterns for treating depression in China in 2006, and the developing tendency for past 4 years. Methods Based on economic levels in different provinces and the convenient sampling, totally 41 hospitals from 10 provinces and cities were selected out. The investigation was conducted during May 22th -28th, 2006, using the revised self-made questionnaire. Results The total number of the sample was 1354, including outpatients （68.0% ） and with pharmacotherapy, and the antidepressants most frequently prescribed were paroxetine （24.4% of the 1354 patients）, fluoxetine （20.3% ）, venlafaxine （19.5%）, citalopram （11.0%）, sertraline （6.3% ）,and mirtazapine （4.1% ）, while 219 patients （ 17.1% ） were treated with TCAs. 62.3% of patients were treated with SSRIs, and most of them administered monotherapy. The frequency of benzodiazepine,antipsychotics and mood stabilizers used were 43.6%, 20.8% and 6.5%, respectively. Comparing to the outpatients, the frequency to use the benzodiazepine and antipsychotics for the inpatients was higher （P 〈 0.05）. And more patients in acute phase used benzodiazepine than those who were in maintenance phase （P 〈 0.01 ）. Conclusion Novel antidepressants are the mainstream to treat patients with depression in China, the tendency of antidepressants prescription pattern matches the development of treatment outcome and treatment techniques for depression.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2010年第4期206-210,共5页
Chinese Journal of Psychiatry
关键词
抑郁
抽样研究
抗抑郁药
处方
药物
Depression
Sampling studies
Antidepressive agents
Prescriptions, drug
