摘要
目的探讨重组人脑利钠肽(rh BNP)对急性心衰患者血浆脑利钠肽(BNP)、去甲肾上腺素(NE)及心功能的影响。方法将108例急性心力衰竭患者随机分为rh BNP组和对照组各54例。观察两组治疗后血浆BNP及NE水平、心功能及临床疗效。结果rh BNP组治疗后血浆BNP、NE水平较对照组下降更明显(P<0.05)。rh BNP组左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室舒张末期容量(LVEDV)及左室收缩末期容量(LVESV)均较治疗前明显改善(P<0.05)。除LVESD外,rh BNP组各指标改善程度均优于对照组(P<0.05)。治疗2周后rh BNP组心功能改善的总有效率为90.7%,明显高于对照组75.9%的总有效率(P<0.05)。治疗后1年内rh BNP组心脏不良事件发生率(16.7%)低于对照组(40.70%),差异有统计学意义(P<0.05)。结论 rh BNP能有效地拮抗急性心衰患者BNP、NE等神经-内分泌激素的过度激活,明显改善患者的心功能状况。
Objective To explore the impact of recombinant human brain natriuretic peptide on plasmabrain natriuretic peptide（BNP）level, norepinephrine（NE） level and cardiac functionin patients with acute heart failure. Methods 108 cases of patients with acute heart failure were randomly divided into control group and rh BNP group. The plasma BNP and NE levels, cardiac function indexes, clinical curative effect after treatment were observed in two groups. Results The plasma BNP and NE levels after treatment in rh BNP group were significantly lower than those in control group. The cardiac function indexes such as LVEF, LVEDD, LVEDV and LVESV were improved after treatment in varying degrees, and the degrees of improvement in rh BNP group（exclusive of LVESD） were better than those in control group（P 〈0.05）. The total effective rate of cardiac function improvement at 2 weeks after treatment was 90.7% in rh BNP group,and significantly higher than 75.9% in control group（P 〈0.05）. Conclusion rh BNP can confront effectively the excessive activation of nerve-endocrine hormone such as BNP and NE and improve cardiac function.
出处
《热带医学杂志》
CAS
2016年第8期1026-1029,共4页
Journal of Tropical Medicine
关键词
重组人脑利钠肽
急性心力衰竭
脑利钠肽
去甲肾上腺素
心功能
Recombinant human brain natriuretic peptide（rh BNP）
Acute heart failure
Brain natriuretic peptide
Norepinephrine
Cardiac function
