摘要
目的:探讨血清B型利钠肽前体(proBNP)和血压变异性在非心源性急性脑梗死患者临床应用中的价值。方法:抽取86例非心源性急性脑梗死患者作为病例组,同期选取40例健康体检志愿者作为对照组,对比分析2组研究对象血清pro-BNP水平、血压变异性相关指标。结果:病例组血清pro-BNP水平为(984.63±148.67)ng/L,明显高于对照组的(138.44±30.75)ng/L(P<0.01)。两组研究对象24 h收缩压变异系数、24 h舒张压变异系数、24 h收缩压标准差、24h舒张压标准差、独立于均值的血压变异系数等比较,差异有统计学意义(P<0.01)。血清proBNP水平与血压变异性相关指标24 h收缩压变异系数、24 h舒张压变异系数、24 h收缩压标准差、24 h舒张压标准差、独立于均值的血压变异系数等呈正相关。死亡组血清pro-BNP水平为(1 326.36±156.85)ng/L,明显高于存活组的(910.28±118.47)ng/L,差异有统计学意义(P<0.01)。两组患者24 h收缩压变异系数、24 h舒张压变异系数、24 h收缩压标准差、24 h舒张压标准差、独立于均值的血压变异系数等血压变异性指标比较,差异均有统计学意义(P<0.05)。结论:血清pro-BNP水平及血压变异性与非心源性急性脑梗死患者预后密切相关,可与其他临床诊断指标和标记物对非心源性急性脑梗死预后诊断。
AIM： To discuss the application of serum B type natriuretic peptide precursor and blood pressure variability in patients with non-eardiogenie ischemic stroke. METHODS： Eighty-six patients with non cardiogenic acute cerebral infarction were selected as the case group, and 40 healthy volun- teers were selected as control group. The serum lev- els of pro-BNP and blood pressure variability were compared between the two groups. RESULTS：The level of serum pro-BNP in the case group was （984.63 ± 148.67） ng/L, which was significantly higher than that of the control group （138.44 ± 30.75） ng/L （P 〈 0.01 ）. The 24 h systolic pres- sure variation coefficient（24 h SBPCV） , 24 h dias- tolic pressure variation coefficient （24 h DBPCV）, 24 h systolic pressure standard deviation （24 h SB- PSD ） , 24 h diastolic pressure standard deviation （24 h DBPSD） and comparison of blood pressure varia- bility coefficients independent of mean （ VIM ） be-tween the two groups were statistically significant （P 〈 0.01 ）. Serum pro-BNP was positively correlated with 24 h SBPCV, 24 h DBPCV, 24 h SBPSD, 24 h DBPSD. The serum pro-BNP level in the death group was （ 1 326.36± 156.85 ） ng/L, which was significantly higber than that of the survival group （910.28±118.gT）ng/L （P〈0.01）. The differ- ence of 24 h SBPCV, 24 h DBPCV, 24 h SBPSD, 24 h DBPSD,VIM between the two groups was sta- tistically significant （ P 〈 0.05 ）. CONCLUSION ： The level of serum pro-BNP and the variation of blood pressure are closely related to the prognosis of patients with non- cardiogenic acute cerebral infarction.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2017年第5期570-573,588,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省医药卫生项目(2012KYB224)
关键词
非心源性急性脑梗死
血清B型利钠肽前体
血压变异性
预后
non-eardiogenic ischemic stroke
serum B type natriuretie peptide
blood pressurevariability
prognosis
