摘要
目的分析血栓通联合综合干预对急性脑梗死(ACI)患者神经功能康复情况及血清可溶性血管细胞黏附分子1(sVCAlVI-1)、可溶性细胞间黏附分子1(slCAM-1)、血管内皮生长因子(VEGF)、血管性血友病因子(vWF)水平的影响。方法选择120例ACI患者,以随机数表法分为联合组与长春西汀组,各60例。2组均接受基础治疗,同时予长春西汀组注射用长春西汀治疗,联合组在长春西汀组基础上予血栓通注射液治疗,2组均治疗2周,并于治疗期间予综合干预。观察2组治疗2周后的疗效,比较2组治疗前、治疗2周后的临床症状评分、血小板参数、神经功能指标及血清细胞因子。结果治疗2周后,联合组总有效率(96.67%,58/60)高于长春西汀组(86.67%,52/60)(P<0.05)。治疗2周后,2组改良Barthel指数(MBI)、Berg平衡量表(BBS)评分、血小板分布宽度(PDW)、血小板计数(PLT)、血小板平均体积(MVP)及血清神经生长因子(NGF)、VEGF水平高于治疗前,联合组高于长春西汀组(P<0.05);2组美国国立卫生研究院卒中量表(NIHSS)评分及血清神经元特异性烯醇化酶(NSE)、钙结合蛋白β(S-100β)、sVCAM-1、slCAM-1、vWF水平低于治疗前,联合组低于长春西汀组(P<0.05)。结论血栓通联合综合干预可改善ACI患者血清sVCAM-1、slCAM-1、VEGF、vWF水平及血小板参数,抑制病情进展,有效缓解临床症状,促进神经功能康复,疗效显著。
Objective To analyze the effect of Xueshuantong combined with a comprehensive intervention on the rehabilitation of neurological function and the serum levels of the soluble vascular cell adhesion molecule-1 (sVCALVI-1),soluble intercellular adhesion molecule-1 (sICAM-1),vascular endothelial growth factor (VEGF) and von Willehemophilia factor (vWF) in patients with acute cerebral infarction (ACI).Methods A total of 120 patients with ACI were selected and divided into a combination group and a vinpocetine group by the random number table method,with 60 cases in each group.Both groups received a basic treatment,while the vinpocetine group received vinpocetine for injection,and the combination group was treated with Xueshuantong Injection based on the vinpocetine group.Both groups were treated for 2 weeks,and a comprehensive intervention was given during the treatment period.The curative effects of the two groups after 2 weeks of treatment were observed,and the clinical symptom scores,platelet parameters,neurological function indexes and levels of serum cytokines were compared between the two groups before and after treatment for 2 weeks.Results After 2 weeks of treatment,the total effective rate in the combination group (96.67%,58/60) was higher than that in the vinpocetine group (86.67%,52/60) (P<0.05).After 2 weeks of treatment,the modified Barthel indexes (MBI),Berg Balance Scale (BBS) scores,levels of the platelet distribution width (PDW),platelet count (PLT),mean platelet volume (MVP),serum nerve growth factor (NGF) and VEGF in both groups were higher than those before treatment,and the combination group was higher than the vinpocetine group (P<0.05).The National Institutes of Health Stroke Scale (NIHSS) scores and the serum levels of the neuron specific enolase (NSE),calcium binding protein β (S-100β),sVCAM-1,sICAM-1 and vWF in the two groups were lower than before,and those in the combination group were lower than those in the vinpocetine group (P<0.05).Conclusion Xueshuantong combined with the comprehensi
作者
屈海宏
马玉强
李占增
李海娜
QU Haihong;MA Yuqiang;LI Zhanzeng;LI Haina(Department of Neurorehabilitation,Tangshan People’s Hospital,Tangshan 063001,China;Department of Neurology,Tangshan People’s Hospital,Tangshan 063001,China)
出处
《长春中医药大学学报》
2022年第3期301-305,共5页
Journal of Changchun University of Chinese Medicine
基金
河北省卫生和计划生育委员会科研基金项目(20191610)。
关键词
急性脑梗死
血栓通
综合干预
神经功能
血小板参数
细胞因子
acute cerebral infarction
Xueshuantong
comprehensive intervention
neurological function
platelet parameters
cytokines
