摘要
目的：研究及观察宫颈癌患者HPV DNA病毒含量及循环血、组织miR指标的变化情况。方法：选取2014年2月~2015年9月本院收治的72例宫颈癌患者为观察组,同时期的72例健康妇女为对照组,比较两组HPV DNA病毒含量及构成、循环血及组织miR指标,并比较观察组Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者的检测结果。结果：观察组HPV DNA病毒含量及〉500者比例均高于对照组（P〈0.05）,循环血及组织miR-21均高于对照组（P〈0.05）,而循环血、组织miR-126、miR-143及miR-145则均低于对照组（P〈0.05）,观察组Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者的检测结果也存在明显差异（P〈0.05）。结论：宫颈癌患者HPV DNA病毒含量及循环血、组织miR指标的变化情况较大,且其检测水平受宫颈癌分期的影响较大,因此对于疾病的诊断与治疗均有积极的指导意义。
Objective： To study and observe the change status of HPV DNA virus content,circulating blood and tissue miR indexes of patients with cervical cancer. Methods： A total of 72 patients with cervical cancer in our hospital from February 2014 to September 2015 were selected as observation group,72 healthy women at the same period were selected as the control group,then the HPV DNA virus content and constitution,circulating blood and tissue miR indexes of two groups were analyzed and compared,and the detection results of observation group with stage Ⅰ,Ⅱ,Ⅲ and Ⅳ of cervical cancer were compared. Results： The HPV DNA virus content and 500 rates of observation group were all higher than those of control group,the circulating blood and tissue miR-21 were all higher than those of control group,while the circulating blood and tissue miR-126,miR-143 and miR-145 were all lower than those of control group,and the detection results of observation group with stage Ⅰ,Ⅱ,Ⅲ and Ⅳ of cervical cancer all had obvious differences too,all P 0. 05,the differences were all significant. Conclusions： The change status of HPV DNA virus content,circulating blood and tissue miR indexes of patients with cervical cancer are obvious and the influence of cervical cancer stage for the detection results are significant,so it has active guiding significance for the diagnosis and treatment of disease.
出处
《海南医学院学报》
CAS
2016年第16期1841-1843,共3页
Journal of Hainan Medical University
基金
四川省科学技术发展项目(20139847831HK)~~
