摘要
目的:探究乌司他丁静脉滴注联合生大黄煎液灌肠对重症胰腺炎患者的疗效及炎症因子水平的改善效果。方法:随机选取2009年6月—2013年6月医院收治的62例重症胰腺炎患者作为本次研究对象,根据入院时间先后将患者分成观察组和对照组各31例,对照组采用乌司他丁治疗,观察组采用乌司他丁联合大黄煎液灌肠治疗,观察并记录两组患者临床疗效,临床症状消退时间以及肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)等指标变化情况,分析比较。结果:治疗后,观察组共治愈15例,总有效率达93.55%,对照组总有效率只有74.19%,两组比较有统计学意义(P<0.05)。两组患者治疗后TNF-α、IL-6和IL-8含量较治疗前均有显著下降,且观察组明显低于对照组患者,两组比较有统计学意义(P<0.05)。经治疗后所有患者血清淀粉酶、谷丙转氨酶和白细胞计数较治疗前均有显著降低(P<0.05),且观察组与对照组比较有明显差异(P<0.05)。观察组患者腹痛、排气和排便等临床症状恢复时间均明显低于对照组患者,两组比较有统计学意义(P<0.05)。结论:乌司他丁联合大黄煎液灌肠治疗重症胰腺炎患者临床疗效较好,各项临床症状在短时间内得到有效缓解,并且各项炎症因子水平明显降低,炎性反应减轻,有利于控制病情,促进恢复,提高患者生活质量。
Objective： To explore the effect of Ulinastatin intravenous infusion combined with rhubarb decoction enema of improving the efficacy and levels of inflammatory factors in patients with severe pancreatitis. Methods： Sixty- two cases of severe acute pancreatitis patients from June 2009 to June 2013 in our hospital were selected in this study and were randomly divided into the control group（ UTI treatment）,observation group（ Ulinastatin and rhubarb decoction enema）. The clinical efficacy was observed and we recorded two groups＇ clinical remission time and tumor necrosis factor- α（ TNF-α）,interleukin- 6（ IL- 6） and interleukin- 8（ IL- 8） and other indicators changes. Results： After treatment,the observation group had 15 cases cured and the total effective rate 93. 55%. The control group＇s total efficiency was only74. 19%. The two groups were statistically significant（ P〈0. 05）. After treatment,TNF- α,IL- 6 and IL- 8 levels were significantly lower than those before treatment and the observation group＇s were significantly lower than the control group＇s and two groups were statistically significant（ P〈0. 05）. After treatment,both groups＇ serum amylase,alanine aminotransferase and white blood cell count were significantly decreased（ P〈0. 05） and the two groups were statistically significant（ P 〈0. 0 5）. The observation group ＇ s abdominal pain and other symptoms recovery time were significantly lower than the control group ＇s. Two groups were statistically significant（ P〈0. 05）. Conclusion： Ulinastatin combined with rhubarb decoction enema has better clinical efficacy in patients with severe pancreatitis. The clinical symptoms can be effectively alleviated in a short time and significantly reduce the levels of inflammatory cytokines,alleviate the inflammation,help control the disease,promote the recovery and improve the quality of life of patients.
出处
《中华中医药学刊》
CAS
北大核心
2016年第7期1784-1786,共3页
Chinese Archives of Traditional Chinese Medicine
