摘要
目的 分析乌司他丁联合谷氨酰胺治疗急性重症胰腺炎的疗效及对血清炎症因子与肝肾功能的影响.方法 抽取2014年10月至2016年4月68例急性重症胰腺炎患者,根据干预方案不同分为对照组（n=34）和研究组（n=34）.对照组采用常规干预措施,研究组在对照组干预基础上联合采用乌司他丁及谷氨酰胺,两组均持续治疗14 d.统计两组临床疗效、不良反应发生率,对比治疗前后两组血清炎症因子[超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）及白细胞介素-6（IL-6）、白细胞介素-8（IL-8）]、肝肾功能指标[血清肌酐（Scr）、血尿素氮（BUN）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）]水平变化情况.结果 研究组总有效率（94.12%）明显高于对照组（73.53%）,差异有统计学意义（P＜0.05）;治疗前两组血清炎症因子及肝肾功能指标比较差异未见统计学意义（P＞0.05）;治疗后,研究组IL-6[（4.23±0.21）ng/ml]、IL-8[（10.24±1.01）ng/ml]、TNF-α[（8.87±1.11）ng/ml]、hs-CRP[（0.87±0.09）mg/ml]、Scr[（100.76±9.01）μmol/L]、BUN[（4.76±0.77）mmol/L]、AST[（23.76±2.20）U/L]、ALT[（24.81±4.12）U/L]、TBIL[（12.10±1.21）μmol/L]均优于对照组,差异有统计学意义（P＜0.05）.研究组不良反应发生率（5.88%）与对照组（2.94%）比较差异未见统计学意义（P＞0.05）.结论 乌司他丁联合谷氨酰胺治疗急性重症胰腺炎疗效确切,可有效缓解患者临床症状,降低血清炎症因子表达水平,改善肝肾功能,且安全性较高.
Objective To analyze the curative effect of ulinastatin combined with glutamine on severe acute pancreatitis and effect on serum inflammatory cytokines and liver and kidney function.Methods Sixty-eighty patients with acute severe pancreatitis were selected from October 2014 to April 2016. According to the different intervention programs, they were divided into control group （n=34） and study group （n=34）. The control group received routine intervention, the study group received ulinastatin combined with glutamine intervention on the basis of control group. Both of the two groups were continuously treated for 14 days. The clinical efficacy and adverse reactions of the two groups were observed. The serum inflammatory factors [high-sensitivity C- reactive （hs-CRP） protein before and after treatment, tumor necrosis factor alpha （TNF- α） and interleukin -6 （IL-6）, interleukin -8 （IL-8）], liver and kidney function index [serum creatinine （Scr）, blood urea nitrogen （BUN） and aspartic acid transaminase （AST）, alanine aminotransferase （ALT）, total bilirubin （TBIL）] levels were compared.Results The total effective rate of the study group （94.12%） was significantly higher than that of the control group （73.53%）, and the difference was significant （P〈0.05）; There was no significant difference in the serum levels of inflammatory cytokines or liver or kidney function between the two groups （P〉0.05）; after treatment, IL-6 [（4.23±0.21） ng/ml], IL-8 [（10.24±1.01） ng/ml], TNF- α[（8.87±1.11） ng/ml], hs-CRP [（0.87±0.09） mg/ml], Scr [（100.76±9.01） μmol/L], BUN [（4.76±0.77） mmol/L], AST [（23.76±2.20） U/L], ALT [（24.81±4.12） U/L], TBIL [（12.10±1.21） μmol/L] in the study group were better than those in the control group, the differences were significant （P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusions The curative effect of ulinastatin c
出处
《中国实用医刊》
2017年第12期8-11,共4页
Chinese Journal of Practical Medicine
关键词
乌司他丁
谷氨酰胺
急性重症胰腺炎
血清炎症因子
肝肾功能
Ulinastatin
Glutamine
Severe acute pancreatitis
Inflammatory factor
Liver and kidney function
