摘要
为探讨连续性血液净化对重症急性胰腺炎患者中血清疾病相关指标的影响,本研究选取了100例从2013年7月至2016年9月为止本院所收治的重症急性胰腺炎患者作为研究对象。采用随机数字法的方式,将研究对象分为观察组及对照组各50例进行研究。对照组采用常规方法治疗重症急性胰腺炎,观察组则采用连续性血液净化进行治疗。治疗后,采用酶联免疫吸附试验,测定两组治疗前、后IL-6、TNF-a、IL-10以及PCT水平,比较2组临床疗效及对患者血清疾病相关指标的影响。结果显示,观察组治疗后腹痛缓解、白细胞恢复正常、血淀粉酶恢复及住院时间,均短于对照组（p〈0.05）;观察组治疗后IL-6、TNF-a、IL-10及PCT水平,均低于对照组（p〈0.05）,经过治疗,观察组的并发症发生率显示为8.00%,与对照组14.00%相比较,远低于对照组。本研究表明,连续性血液净化对于重症急性胰腺炎患者血清疾病有相当的改善,有助于促进患者病情恢复,临床上值得推广应用。
In order to investigate the effect of continuous blood purification on serum disease related indexes in SAP（severe acute patients with acute pancreatitis）, 100 patients with severe acute pancreatitis in our hospital were selected as research objects from July 2013 to September 2016 in this study. The subjects were divided into control group（n=50） and observation group（n=50） by the random digital method. The control group was treated with routine therapy for severe acute pancreatitis; the observation group was treated with continuous blood purification. After treatment, the levels of IL-6, TNF-a, IL-10 and PCT before and after treatment were measured by enzyme linked immunosorbent assay（Elisa）. The clinical efficacy of 2 groups and the effect on serum disease related indicators were compared. The results showed that the abdominal pain was relieved, the white blood cells returned to normal, the amylase recovered and the time of hospitalization in the observation group were shorter than those in the control group（p〈0.05）. The levelsof IL-6, TNF-a, IL-10 and PCT in the observation group were lower than those in the control group（p〈0.05）, and the incidence of complications in the observation group was 8.00%, which was significantly lower than that in the control group（14.00%）. This study indicated that continuous blood purification could improve serum diseases in patients with severe acute pancreatitis, and might be helpful to promote the recovery of patients’ condition, which would be worth popularizing in clinic.
作者
余小柱
王晓伟
王福安
李瑞玲
梁迎接
郭艳芳
Yu Xiaozhu;Wang Xiaowei;Wang Fuan;Li Ruiling;Liang Yingjie;Guo Yanfang(Pingdingshan University Medicine College, Pingdingshan, 467000;Henan University School of Nursing and Health, Kaifeng, 475004;Henan Uni- versity of Science and Techology School of Nursing, Luoyang, 471023;Pingdingshan Hospital of Traditional Chinese Medicine, Pongdingshan, 467000)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2018年第4期1806-1812,共7页
Genomics and Applied Biology
基金
河南省卫生与计划生育委员会课题:2016年河南省医学教育研究项目(以影视剧为向导的情景教学模式在《急危重症护理学》中的应用)(课题编号:WJLX2016239)
2016年度校级精品资源共享课程(外科护理学)
河南省卫生和计划生育委员会课题:2015年度河南省医学科技攻关项目(健康赋权理论视角下失能脑卒中患者主要照顾着潜力激发的干预研究)(课题编号:201504H013)共同资助
关键词
连续性血液净化
重症急性胰腺炎
血清疾病
相关指标
Continuous blood purification
Severe acute pancreatitis
Serum disease
Related indicators
