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中老年精神分裂症患者高同型半胱氨酸血症与心脑血管疾病的相关性分析 被引量:12

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摘要 目的探讨中老年精神分裂症患者高同型半胱氨酸血症(HHcy)与心脑血管疾病的相关性。方法选择2014年7月1日-12月31日北京市昌平区中西医结合医院住院病人中年龄≥45岁的中老年精神分裂症患者403例为研究对象,收集一般人口学特征、病例资料,采用循环酶法检测血清Hcy水平。以Hcy≥15μmol/L作为高同型半胱氨酸血症的标准,将所有病例分为HHcy组(n=192)及非HHcy组(n=211),分析高同型半胱氨酸血症与心脑血管疾病的相关性。结果男性HHcy的发生率(73/127,57.5%)高于女性(119/276,43.1%)患者(χ^2=7.194,P=0.007);HHcy组合并冠心病(χ^2=46.034,P〈0.001)及脑梗死(χ^2=5.675,P=0.017)的比例高于非HHcy组;二元logistic回归显示:高同型半胱氨酸血症与性别(OR=1.934,P=0.004)及是否合并冠心病有关(OR=1.755,P=0.007)。结论中老年精神分裂症患者常合并心脑血管疾病;男性患者发生高同型半胱氨酸血症的风险高于女性;是否合并冠心病与精神分裂症患者发生HHcy密切相关。
出处 《实用预防医学》 CAS 2016年第7期835-837,共3页 Practical Preventive Medicine
基金 国家高技术研究发展计划(863计划)项目(编号:2011AA02A111)
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