摘要
目的探讨血浆同型半胱氨酸(tHcy)水平与糖尿病肾病(Diabetic nephropathy,DN)发生以及临床分期的相关性。方法检测51例健康人(control,CON组)和76例2型糖尿病患者(按照24h尿白蛋白排泄率分组为无糖尿病并发症组和早期糖尿病肾病组和临床糖尿病肾病组)的血浆同型半胱氨酸,比较各组间血浆同型半胱氨酸水平。结果糖尿病患者组的血浆tHcy水平为(11.85±7.79)μmol/L高于CON组(7.59±1.23)μmol/L,(P<0.01);无糖尿病并发症组血浆tHcy水平为(8.66±2.66)μmol/L;早期糖尿病肾病组血浆tHcy水平为(13.48±3.36)μmol/L;临床糖尿病肾病组组血浆tHcy水平为(25.50±12.41)μmol/L。各组间tHcy水平均有差异极为显著性(P<0.01)。结论糖尿病患者血浆tHcy水平高于CON组,而且随着病程的发展,血浆tHcy水平呈上升趋势,血浆tHcy水平可以作为监测DN发生、发展的一个指标。
Objective To explore the relationship between the total homocyteine （tHcy） in plasma and the occurrence and clinical phasing of diabetic nephropathy. Methods The tHcy levels in plasma of 51 healthy individuals （control group） and 76 Type II diabetic nephropathy patients （the observation group） were determined and analyzed. Results The they levels in diabetic patients was （11.85 ± 7.79） μmol/L, significantly higher than that of the controls of （7.59 ± 1.23）μmol/L （ P 〈 0.001）. While the level of they in diabetic patients without complications was （8.66 ± 2.66）μmol/L. The level of tHcy in diabetic patients at early stage was （13.48 ± 3.36）μmol/L. The they level in clinical diabetlc patients was （25.50 ± 12.41）μmol/L. The differences between each groups were significant （ P 〈 0.01 ）. Conclusion The level of they in observation group is higher than that of the control one and the level of they shows a tendency of increasing along with the elongating of the course of disease. Thus it can be used as an indicator in monitoring the occurrence and development of the diabetic nethropathy.
出处
《中国热带医学》
CAS
2006年第4期610-611,共2页
China Tropical Medicine
基金
江门市科技局2002年第一批科研项目(20020104)
