摘要
目的探讨痹痛消胶囊(青风藤、土茯苓、骨碎补等)对大鼠类风湿性关节炎的治疗作用及其作用的相关机制。方法 70只SD大鼠除10只作为正常对照组,其余皮下注射Freund’s完全佐剂建立类风湿性关节炎大鼠模型,造模成功后分组给药2周,观察给药后痹痛消胶囊高、中、低剂量对类风湿性关节炎大鼠足关节肿胀度、血清超敏C反应蛋白(hs CRP)、白介素-1β(IL-1β)和肿瘤坏死因子α(TNF-α)含有量的影响,以及组织病理学观察。结果痹痛消胶囊明显抑制类风湿性关节炎大鼠足关节肿胀度,显著降低类风湿性关节炎大鼠血清中hs CRP、IL-1β和TNF-α的含有量,明显减轻足关节软骨病变程度。结论痹痛消胶囊具有较好的治疗类风湿性关节炎作用,其作用机制可能与下调其hs CRP、IL-1β、TNF-α的含有量有关。
AIM To observe the therapeutic effect of Bitongxiao Capsules（BTX）（Sinomenii Caulis,Smilacis glabrae Rhizoma,Drynariae Rhizoma,etc.） against rheumatoid arthritis（RA） and its mechanism of action.METHODS Seventy SD rats,except for ten rats as the control group,the rest received SC Freund＇ s complete adjuvant to make the RA rat model.After two weeks,model rats were administered BTX high,medium and low dose.The anti-arthritic effects against RA were studied through observing the changes of paw swelling,high-sensitivity C-reactive protein（hs CRP）,interleukin 1β（IL-1β）,and tumor necrosis factor α（TNF-α） after medication.RESULTS BTX could significantly inhibit RA rats paw swelling,decrease the levels of hs CRP,IL-1β,and TNF-α in the serum of RA rats.CONCLUSION BTX has better therapeutic effect on RA and its mechanism may be related to the down-regulation of hs CRP,IL-1β,and TNF-α.
出处
《中成药》
CAS
CSCD
北大核心
2016年第6期1211-1215,共5页
Chinese Traditional Patent Medicine
基金
广东省科技计划项目(2011B032200016)
