摘要
目的:探讨藏药十味乳香散治疗类风湿性关节炎(RA)的疗效及机制。方法:通过建立Ⅱ型胶原蛋白诱导的RA大鼠模型,测定治疗前后大鼠足踝关节直径、体质量以及利用ELISA法测定白细胞介素17(IL-17)表达量。结果:十味乳香散可降低RA大鼠体内IL-17的含量,2倍剂量组较单倍剂量组降低效果更明显(P<0.05)。十味乳香散可有效缓解踝关节肿胀程度,且2倍剂量组缓解效果更明显(P<0.05)。结论:藏药十味乳香散能有效缓解RA大鼠的足踝关节肿胀程度,其作用机制可能为十味乳香散可降低IL-17含量。
Objective. To evaluate the therapeutic effects and mechanisms of Shiwei ruxiangsan in treatment of rheumatoid arthritis（RA）.Methods. The RA rat model induced by type Ⅱ collagen were established. The ankle joint diameter, weight of rats and the ELISA method for determination of interleukin 17 （IL-17） expression were measured before and after treatment.Results. The Shiwei ruxiangsan could reduce the levels of IL-17, single does of Shiwei ruxiangsan could reduce the content of IL-17, the effect of the double does was more obvious.Conclusion. Shiwei ruxiangsan can effectively relieve RA rats swelling degree of ankle joint.IL-17 levels associated with the severity of the inflammation,may be the mechamism of action of Shiwei ruxiangsan.
作者
丁佳栋
张春江
DING Jiadong ZHANG Chunjiang(Lanzhou General Hospital of PLA, Lanzhou 730050, Chin)
出处
《西北国防医学杂志》
CAS
2017年第6期368-371,共4页
Medical Journal of National Defending Forces in Northwest China
