摘要
目的:探讨运用中医的补肾通络方联合西药治疗类风湿性关节炎继发骨质疏松的临床疗效。方法:选择2013年1月至2015年1月期间于我院住院治疗的类风湿性关节炎继发骨质疏松的患者共72例,随机分成2组,治疗组与对照组,治疗组运用中医补肾通络方联合使用鲑鱼降钙素针剂,1支/d肌注,维D2磷酸氢钙片1片/d口服,连续服用2个月。对照组只运用鲑鱼降钙素针剂,维D2磷酸氢钙片,连续服用2个月。比较2组患者治疗前后的临床治疗效果、临床症状的改善和骨代谢的情况。结果:2组患者治疗组的总有效率为94.5%,对照组为69.5%,治疗组优于对照组,差异有统计学意义(P<0.01)。治疗前2组患者的钙离子、红细胞沉降率和骨密度统计结果无差异,2组无统计学意义(P>0.05)。经分别治疗后,红细胞沉降率指标明显下降,钙离子与骨密度指标明显升高,2组治疗后的指标差异有统计学意义(P<0.01)。治疗前2组患者的晨僵时间、关节压痛、关节肿胀和关节功能统计结果无差异,2组无统计学意义(P>0.05)。治疗后治疗组的晨僵时间、关节压痛、关节肿胀和关节功能均明显改善,且明显优于对照组,2组差异有统计学意义(P<0.01)。结论:运用中医补肾通络的治疗方法联合西医治疗类风湿性关节炎继发骨质疏松,具有明显的临床疗效,能有效改善患者的临床症状,缓解或改善骨质流失,调节骨代谢,缓解骨质疏松。
Abstract Objective： To study the clinical effect of the treatment of the rheumatoid arthritis （RA） and secondary osteoporosis （OP） with kidney-tonifying and collaterals-dredging medicinals combined with western medicine. Methods： Total 72 cases in the hospital from January 2013 to January 2015 during the hospitalization for rheumatoid arthritis with secondary osteoporosis were ran- domly divided into two groups： study group and control group. Study group was treated with kidney-tonifying and collaterals-dred- ging medieinals with salmon ealcitonin injection every day as well as oral I~ calcium hydrogen phosphate for two months. The con- trol group only received salmon ealcitonin injection and dimension D2 calcium hydrogen phosphate, also for two months. Clinical therapeutic effects, the improvement of clinical symptoms and the bone metabolism of two groups were compared before and after treatment. Results： The total effective rate of study group was 94.5%, better than the control group＇ s 69.5%, the difference of the two group was significant （P 〈 0.01 ）. The calcium ions, erythrocyte sedimentation rate （ESR） and bone mineral density （BMD） results of the two groups had no statistical significance compared with before the treatment （P 〉 0.05 ）. After the treat- ment, the ESR declined obviously, calcium and bone mineral density rose significantly （P 〈 0.01 ）. The situation of morning stiff- ness, joint tenderness, joint swelling and joint function of the both group had no statistical differences compared with before the treatment （P 〉 0.05 ）. After the treatment, duration of morning stiffness, joint tenderness, joint swelling and joint function of the study group were significantly improved, and the results were superior to the control group significantly （P 〈 0. 01 ）. Conclusion： Kidney-tonifying and collaterals-dredging medicinals combined with western medicine has significant clinical effect in the treatment of rheumatoid arthritis and secondary osteoporo
出处
《世界中医药》
CAS
2016年第5期842-845,共4页
World Chinese Medicine
基金
广西壮族自治区自然科学基金项目(编号:gx2919223)
关键词
类风湿性关节炎
骨质疏松
补肾通络
中西医结合
Rheumatoid arthritis
Osteoporosis
Kidney-tonifying and collaterals-dredging
Integration of Chinese and Westernmedicine
