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非甾体抗炎药治疗类风湿性关节炎的现状与展望 被引量:4

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摘要 类风湿性关节炎(rheumatoid arthritis,RA)是一种以累及周围关节为主的多系统炎症性的自身免疫病。据有关资料统计我国发病率约为0.32%-0.36%。临床表现为受累关节疼痛、肿胀、功能下降、病情呈持续和反复发作过程。该病严重影响患者生活质量,且与关节畸形及病程长短有关日,同时也是造成我国人群丧失劳动力和致残的主要病因之一。非甾体抗炎药(non—steroidal anti—inflammatory drugs,NSAIDs)通过抑制环氧酶(cyclooxy—genase,COX)的活性和阻断下游前列腺素E(Prostaglandin E2,PGE2)的产生而发挥药效。从1899年阿司匹林上市以来,NSAIDs在临床的应用已有百余年历史,
出处 《天津医药》 CAS 北大核心 2009年第8期716-719,共4页 Tianjin Medical Journal
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