摘要
HIV/AIDS是由HIV引起的患者免疫系统进行性损伤的免疫缺陷性疾病,炎性反应在HIV/AIDS的疾病发展进程中起重要作用。NF-κB是引起炎性反应的关键转录因子,可调节多种基因的表达,因此,NF-κB介导的炎性反应是HIV/AIDS患者的疾病发展的机制之一。系统生物学研究发现,HIV/AIDS不同中医证候患者有不同的分子物质基础,在HIV/AIDS肺脾气虚证患者的转录组学检测中发现,有与NF-κB介导的炎性反应相关的基因异常表达,可能与HIV/AIDS肺脾气虚证的疾病发展有一定关系,探讨NF-κB介导的炎性反应在HIV/AIDS肺脾气虚证中的研究现状,为下一步HIV/AIDS肺脾气虚证的机制研究提供新的研究点,为中医药治疗HIV/AIDS的研究提供新的靶点。
HIV/AIDS is an immunodeficiency disease caused by human immunodeficiency virus(HIV), and the inflammatory response plays an important role in the development of HIV/AIDS. NF-κB is a key transcription factor that causes inflammation and regulates the expression of multiple genes. Therefore, the inflammatory response mediated by NF-κB is one of the mechanisms for the disease development of HIV/AIDS. Systems biology studies have found that HIV/AIDS patients with different syndromes have different molecular material foundation. The transcriptome study found that the NF-κB mediated gene abnormal expression associated with the inflammatory response. It may be related to HIV/AIDS disease. Exploring the NF-κB mediated inflammatory response in HIV/AIDS research status in HIV/AIDS patients with lung and spleen qi deficiency syndrome to provide a new research point for the next step of mechanism research of HIV/AIDS with lung and spleen qi deficiency syndrome and a new target for research on the treatment of HIV/AIDS with traditional Chinese medicine.
作者
刘飒
谢世平
陈玉龙
许前磊
张淼
张海燕
马素娜
王娟
LIU Sa;XIE Shi-ping;CHEN Yu-long;XU Qian-lei;ZHANG Miao;ZHANG Hai-yan;MA Su-na;WANG Juan(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第2期546-549,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.U1704180
No.81403342)
国家"十二五"科技重大专项项目(No.2012ZX10005001-005)
河南省创新人才项目(No.174200510024)~~
