摘要
人类免疫缺陷病毒感染与获得性免疫缺陷综合征(艾滋病)作为一种新发的传染病,中医学没有明确的记载,经过近30年医家们运用中医药的临床实践,取得了显著的临床疗效,研发出了大量的有效方药,但在中药新药研发方面进展缓慢,目前治疗艾滋病的中药新药仅唐草片一个品种,在一定程度上限制了中医药防治艾滋病作用的发挥。笔者通过对治疗艾滋病中药研究现状的分析,探讨限制治疗艾滋病中药新药研发的瓶颈,如缺少理想的动物模型,艾滋病的中医临床研究混杂因素过多,提出在深入开展动物模型研究的基础上,注重中医复方作用机制研究,尤其体外抗病毒、免疫调节活性成分筛选,为更好的研发治疗艾滋病中药新药提供证据。
Human immunodeficiency virus infection and acquired immune deficiency syndrome（ HIV/AIDS） are new infectious diseases,with no clear record of traditional Chinese medicine（ TCM）. Through nearly30 years of clinical practices,TCM doctors have made remarkable clinical achievements,developed a lot of effective prescriptions,but still lagged behind in research and development of new TCM. Currently,the only new TCM for treating AIDS is Tangcao tablets,which restricts the role of TCM in prevention and control of AIDS to a certain extent. Through the analysis of the current research on TCMs in treatment of AIDS,the author explored the bottlenecks restricting new AIDS TCM research and development,such as the lack of ideal animal model,and the large number of confounding factors for AIDS TCM clinical research. Therefore,the author paid attention to the TCM compound mechanism research on the basis of in-depth research on animal models,especially screening of in vitro antivirus and immune regulating active ingredients,so as to provide the basis for better developing HIV/AIDS TCMs.
作者
许前磊
许二平
谢世平
徐立然
郭会军
XU Qian-lei XU Er-ping XIE Shi-ping XU Li-ran GUO Hui-jun(The First Affiliated Hospital of ttenan University of Chinese Medicine, Zhengzhou 450000, China AIDS Study Institute, Henan University of Chinese Medicine, Zhengzhou 450008, China Henan Provincial Key Laboratory of Viral Diseases Control with Traditional Chinese Medicine, Zhengzhou 450008, China Henan University of Chinese Medicine, Zhengzhou 450046, China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第20期196-202,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家"重大新药创制"科技重大专项(2012ZX10005-001-005
2013ZX10005-001-002)
国家自然科学基金项目(81403342)
河南省高校科技创新人才支持计划项目(16HASTIT031)
河南省高等学校青年骨干教师资助计划项目(2015GGJS-097)
河南省中医药科学研究专项重点项目(2015ZY01004)
河南中医学院省属科研业务费专项(2014KYYWF-YQ009)
河南中医学院科技创新人才支持计划项目(2015XCXRC06)
关键词
艾滋病
中药
研究现状
分析
HIV/AIDS
traditional Chinese medicine
current research
analysis
