摘要
目的探讨多发性骨髓瘤合并肾功能不全患者的临床特点。方法随机抽取102例MM患者的临床资料,按照患者出现肾功能不全的时间不同分为A组、B组、C组。A组34例,B组12例,C组56例。A组患者在初诊时发现合并肾功能不全;B组患者为初诊时无肾功能不全者,在疾病进展过程中出现肾功能不全;C组为疾病治疗过程中未出现肾功能不全的患者。观察患者临床表现、免疫分型及临床疗效。结果 A组和B组患者Scr、血清钙、UA、β2-MG、浆细胞水平显著高于C组,差异有统计学意义(P<0.05)。A组LDH水平显著低于B组,差异有统计学意义(P<0.05)。46例合并肾功能不全的患者中,Ig Aλ轻链型的比例显著高于Ig Ak轻链型,差异有统计学意义(P<0.05)。C组中位生存期显著高于A组和B组,差异有统计学意义(P<0.05)。结论多发性骨髓瘤合并肾功能不全患者临床表现为高水平的Scr、血清钙、UA、β2-MG、浆细胞,而且Ig Aλ轻链型的比例较高。
Objective To explore the clinical characteristics of multiple myeloma combine with renal insufficiency.Methods 102 cases of patients with multiple myeloma were divided into group A（ 34 cases）,group B（ 12 cases）,and group C（ 56 cases） according to the time of renal insufficiency. Renal insufficiency of group A were found at first diagnosis,renal insufficiency of group B appeared during progression,group C had no renal insufficiency. Clinical manifestation,immunophenotyping,and clinical effects were observed. Results The levels of Scr,blood calcium,UA,β2-MG,plasma cell of group A and group B were higher than those of group C（ P〈0. 05）. The levels of LDH of group A were lower than that of group B（ P〈0. 05）. Among 46 cases of patients with renal insufficiency,the ratio of Ig Aλ light chain type was higher than that of Ig Ak light chain type（ P〈0. 05）.The mean survival of group C was higher than that of group A and group B. Conclusion Clinical manifestation of multiple myeloma with renal insufficiency are high levels of Scr,blood calcium,UA,β2-MG,and plasma cell,and high ration of Ig Aλ.
出处
《实用癌症杂志》
2016年第5期836-838,共3页
The Practical Journal of Cancer
关键词
多发性骨髓瘤
肾功能不全
临床特点
Multiple myeloma
Renal insufficiency
Clinical characteristics
