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多发性骨髓瘤干细胞移植术后伴异常蛋白带与疗效和预后的相关性 被引量：4

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摘要 多发性骨髓瘤（multiple myeloma,MM）是B淋巴细胞恶性克隆性疾病,虽然传统的化疗可以使病情得到一定控制,但很少有患者能够取得完全缓解,更不能治愈。近年来,MM患者采用自体或异体基因造血干细胞移植治疗呈逐年增多趋势,并取得了显著的临床疗效,然而造血干细胞移植术后,患者常常出现不同于初诊类型的新的M蛋白或寡克隆蛋白带,或者初诊M蛋白的迁移率发生了变化。
作者 黄前川 张新华
机构地区 广州军区武汉总医院
出处 《实用癌症杂志》 2016年第1期169-170,共2页 The Practical Journal of Cancer
关键词 多发性骨髓瘤 干细胞移植术 异常蛋白条带
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Hall SL, Tate J, Gill D, et al. Significance of abnormal protein bands in patients with multiple myeloma following autologous stem cell trans- plantation[ J). Clin Biochem Rev ,2009,30 ( 3 ) : 113-118. 被引量：1
  • 2Mark T, Jayabalan D, Coleman M, et al. Atypical serum immunofix- ation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma [ J~. Br J Haemato1,2008,143 (5) :654-660. 被引量：1
  • 3Zou D, An G, Zhu G, et al. Secondary monoclonal gammopathy of un- determined significance is frequently associated with high response rate and superior survival in patients with plasma cell dyscrasias[ J]. Biol Blood Marrow Transplant ,2014,20 ( 3 ) :319-325. 被引量：1
  • 4王荷花,李娟,刘俊茹,郑冬,谷景立,颜绵生,邹外一,许多荣.异常蛋白条带在含硼替佐米方案诱导序贯自体造血干细胞移植治疗多发性骨髓瘤患者中的意义[J].中华血液学杂志,2013,34(4):327-331. 被引量：3
  • 5Wadhera RK, Kyle RA, Larson DR, et al. Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of undetermined significance in patients with multiple myeloma ~ J 3. Blood, 2011,118 ( 11 ) :2985-2987. 被引量：1
  • 6Tovar N, de Larrea CF, Ar6stegui JI, et al. Natural history and prog- nostic impact of oligoclonal humoral response in patients with multiple myeloma after autologous stem cell transplantation: long-term results from a single institution ~ J 3. Haematologica, 2013,98 ( 7 ) : 1142- 1146. 被引量：1
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  • 8Schmitz MF, Otten HG, Franssen LE, et al. Secondary monoclonal ga- mmopathy of undetermined significance after allogeneic stem cell transplantation in multiple myeloma ( J 1. Haematologica, 2014,99 (12) : 1846-1853. 被引量：1
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二级参考文献13

  • 1Blad6 J, Samson D, Reeee D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Br J Haematol, 1998, 102: 1115-1123. 被引量：1
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  • 4武永吉.多发性骨髓瘤//张之南,沈悌.血液病诊断及疗效标准.3版.北京:科学出版社,2007:232-235. 被引量：1
  • 5Wadhera RK, Kyle RA, Larson DR, et al. Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of un- determined significance in patients with multiple myeloma. Blood, 2011, 118: 2985-2987. 被引量：1
  • 6Hovenga S, de Wolf JT, Guikema JE, et al. Autologons stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation. Bone Marrow Transplant, 2000, 25: 723-728. 被引量：1
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  • 8Mark T, Jayabalan D, Coleman M, et al Atypical serum immu- nofixation patterns frequently emerge in immunomodulatory thera- py and are associated with a high degree of response in multiple myeloma. Br J Haematol, 2008,143:654-660. 被引量：1
  • 9Gerritsen E J, Van To! M J, Van' t Veer MB, et al. Clonal dysregulation of the antibody response to tetanus-toxoid after bone marrow transplantation. Blood, 1994, 84 : 4374-4352. 被引量：1
  • 10Xiang Z, Cutler A J, Brownlie R J, et al. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immu- no1, 2007, 8 : 419-429. 被引量：1

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实用癌症杂志
2016年 第1期

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