摘要
目的检验初发的多发性骨髓瘤患者发生高钙血症的比例,比较经白蛋白校正前后患者血钙浓度的变化情况。方法选取我院自1993年以来初发骨髓瘤患者110例,测定其血钙浓度值、血清蛋白值,以校正钙值(mmol/L)=血清总钙测定值(mmol/L)+(40-血清白蛋白测定值)×0.02mmol/L,以t检验及NewmanKeuls检验来检验校正前后,各型、亚型,各期骨髓瘤患者的血钙浓度比较是否有统计学意义。结果校正后高钙比例为25.4%,全体骨髓瘤患者血钙浓度经白蛋白校正前后分别为(2.3819±0.3663)mmol/L、(2.5027±0.3851)mmol/L(P<0.01);A、B亚型骨髓瘤患者血钙浓度具有显著差异(P<0.01)。结论由于低蛋白血症的出现使临床上对高钙血症的判断有一定偏差,需要结合血清蛋白浓度具体判断;骨髓瘤患者有较高的高钙血症发生率,与其是否有肾功能不全有一定的相关性。
Objective To ascertain the incidence of hypercalcaemia in patients with newly diagnosed multiple myeloma (MM).Methods We evaluated serum calcium concentrations in 110 patients with incipient MM (79 male and 31 female), aged between 30 and 91 years,admitted to Changzheng Hospital since 1993.Their serum calcium levels(mmol/L) were corrected according to the following formula:total calcium(mmol/L)+ 0.02×[40 serum albumin concentration (g/L)] mmol/L.Results Based on serum calcium levels, hypercalcaemia was detected in 19 patients with MM (17.27%) before adjustment and 28 patients after adjustment (25.4%).There was significant difference between the mean serum calcium concentrations (±s) before and after adjustment in general MM patients (2.3819±0.3663 mmol/L and 2.5027±0.3851 mmol/L, P<0.01 ) .The serum calcium concentration and albumin adjusted serum calcium concentration in patients with isoform A or B MM were also significantly different (P<0.01).Conclusion Hypercalcaemia is a common laboratory finding in patients with MM; hypoproteinemia makes their diagnosis of hypercalcaemia hypoevaluated. Hence,we should use albumin adjusted serum calcium concentration in diagnosis of hypercalcaemia. Patients with MM have high incidence of hypercalcaemia ,which is likely correlated with renal function.
出处
《武警医学》
CAS
2004年第9期672-675,共4页
Medical Journal of the Chinese People's Armed Police Force
