摘要
目的:观察及分析应用伊班膦酸钠治疗多发性骨髓瘤患者骨痛及高钙血症的疗效。方法:选择2005年1月～2010年4月我科应用伊班膦酸钠治疗的多发性骨髓瘤患者30例,对患者资料进行回顾性分析。30例多发性骨髓瘤患者每21天应用伊班膦酸钠4 mg静点,观察使用伊班膦酸钠前后骨痛缓解率及血钙浓度变化,判定伊班膦酸钠治疗多发性骨髓瘤的疗效。结果:30例患者应用伊班膦酸钠前血钙浓度为(3.22±1.2)mmol/L,用药后血钙浓度为(2.42±0.57)mmol/L,用药后血钙浓度明显减低,差异有统计学意义。用药后骨痛缓解总有效率达80.00%。结论:伊班膦酸钠能有效缓解多发性骨髓瘤患者骨痛,降低血钙,治疗高钙血症。
Objective： To observe and analyze the therapeutic effect of treatment with Ibandronate on bone pain and hy-percalcemia in patients with multiple myeloma（MM）.Methods：From year 2005 to 2010,30 cases of multiple myeloma treated by Ibandronate were selected,the clinic data of those cases were analyzed retrospectively.30 cases of multiple myeloma received intraveous injection of Ibandronate（4 mg） once three weeks.We observed the pain remission rate and serum calcium concentration between before and after treatment by Ibandronate,and to judgement of the effect of MM treated with Ibandronate.Results：The serum calcium concentration of all the 30 cases pretreatment was（3.22±1.2） mmol/L,and post-treatment was（2.42±0.57） mmol/L.The serum calcium levels were decreased in patients with MM after treatment by Ibandronate.The difference was statistically significant（P〈0.05）.The total effective rate of pain remission was 80.00%.Con-clusion： Ibandronate can effectively relieve bone pain caused by Multiple Myeloma and drop serum calcium,to treat hyper-calcemia.
出处
《中国医药导报》
CAS
2010年第31期56-57,共2页
China Medical Herald
