摘要
目的探讨中青年隐源性脑梗死（cryptogenic cerebral infarction,CCI）合并卵圆孔未闭（patent foramen ovale,PFO）患者临床及磁共振成像（magnetic resonance imaging,MRI）特点。方法选取27例18~55岁CCI患者为研究对象,收集其临床资料,采用心脏MRI检测其PFO存在情况,根据结果分为PFO组和非PFO组,对比两组间的临床资料及MRI影像特点差异。结果 27例中青年CCI患者中PFO阳性者13例（48.15%）,阴性者14例（51.85%）,PFO阳性者房间隔处均可见不同程度的局限性缺损及动态血流信号。PFO组患者具有较低的高血压、高血脂、糖尿病、冠心病病史及颈动脉斑块、脑动脉狭窄阳性构成比,其脑梗死家族史、高同型半胱氨酸血症阳性构成比较高,MRI示其脑梗死病灶主要分布于前循环,以单血供区、﹤2 cm的单发小穿支梗死为主,但两组间各临床资料及梗死灶分布差异均无明显统计学意义（P均〉0.05）。结论中青年CCI合并PFO发生率较高,多无典型的临床及梗死灶影像分布特征,心脏MRI技术可以作为其检测手段之一。
Objective To evaluate the clinical and imaging characteristics of young and middle-aged cryptogenic cerebral infarction（ CCI） patients with patent foramen ovale（ PFO）. Methods Totally 27 CCI patients aged from 18 to 55 years old were chose as trial group,all patients clinical data were collected and the presence of PFO was observed by cardiac MRI. Divided the patients into PFO group and non PFO group,compared the clinical data and imaging characteristics between the two groups. Results Total of 27 CCI patients were investigated,including 13 patients（ 48. 15%） with PFO and14 patients（ 51. 85%） without PFO. In all CCI patients with PFO,different degrees of localized defect and dynamic blood signals could be observed in the atrial septum. The proportions of positive history of hypertension,hyperlipidemia,diabetes,coronary artery disease,and carotid plaque,cerebral vascular stenosis in PFO group were lower than that in non-PFO group,the proportions of positive family history of cerebral infarction and hyperhomocysteine in PFO group were higher. MRI showed the cerebral lesions in PFO group mainly distributed in the anterior circulation area,in the form of single blood supply area,less than 2 cm single small perforator infarction,but there were no significant difference of the clinical and imaging characteristics between two groups（ P〉0. 05）. Conclusion CCI combined with PFO in young and middle-aged patients had a higher incidence,and most of them had no typical clinical and infarct distribution characteristics,Cardiac MRI can be used as an effective method for the diagnosis of PFO.
出处
《中风与神经疾病杂志》
CAS
北大核心
2016年第4期342-345,共4页
Journal of Apoplexy and Nervous Diseases
基金
新乡市重点科技攻关计划基金资助项目(ZG13021)
关键词
卵圆孔未闭
磁共振成像
隐源性脑梗死
脑梗死
Patent foramen ovale
Magnetic resonance imaging
Cryptogenic cerebral infarction
Cerebral infarction
