摘要
目的：对7～11岁注意缺陷多动障碍（ attention deficit hyperactivity disorder，ADHD ）和正常儿童汉字任务ERP进行研究，探讨ADHD与正常儿童语义加工发展特点的差异。方法两组儿童为ADHD 83例、正常儿童93名，7～11岁分五个年龄组。实验采用ERP 汉字刺激任务（相关、不相关及假字三种条件）。结果 ERP的N400波幅及潜伏期比较：（1）语义相关：7岁正常儿童N400波幅高于11岁[（－10．67±4．39）μV，（－4．62±3．55）μV；P＝0．005]；8岁ADHD高于其他组[（－10．77±6．66）μV， F＝2．54， P＝0．046]。10岁、11岁正常儿童潜伏期较8岁组延长[（342．9±52．5）ms，（351．8±62．1）ms，（311．7±33．1）ms， P＜0．05]，11岁ADHD儿童潜伏期长于其他组[（391．7±82．2）ms， P＝0．033]。（2）语义不相关：10岁正常儿童N400波幅高于其他组[（－16．67±7．98）μV， P＝0．014]， ADHD组各年龄段差异无统计学意义；ADHD与正常组N400潜伏期各年龄段差异均无统计学意义。（3）假字条件：9岁正常儿童N400波幅高于其他年龄[（－16．08±7．14）μV， P＜0．05]，11岁ADHD儿童N400波幅高于7、9、10岁[（－18．81±10．58）μV， P＜0．05]。8、9岁正常儿童潜伏期较短[（319．1±26．1） ms，（319．6±24）ms；P＜0．05]，ADHD儿童潜伏期各年龄段差异无统计学意义。结论 ADHD于语义相关条件的N400波幅与潜伏期分别在8、9岁明显变化，假字在11岁明显发展，均晚于正常儿童1个以上年龄段。 ADHD儿童语义加工和正字法认知的能力发展迟缓。 N400能较好反映儿童早期语言认知能力，有较好早期诊断具有价值。
Objective To explore the developmental characteristics of semantic processing of chil-dren with attention deficit hyperactivity disorder（ ADHD） by comparing the event related potential in normal children and ADHD children （ ages 7-11 years old） .Methods 83 ADHD children and 93 normal children ranging from 7 to 11-year were divided into 5 groups to analyze the difference of the amplitude and latency of ERP N400 in three conditions：the related,unrelated and pesudoword after the Chinese character word visual stimulus task.Results （1） The related condition：the amplitude of the 7 years old normal children group was higher than 11 years old（（-10.67±4.39）μV,（-4.62±3.55）μV;P=0.005）;and the amplitude was highest in 8 years old group in children with ADHD（ （-10.77±6.66） ms, F=2.54, P=0.046） .The latency in normal children was shorter at 8 years old（（311.7±33.1） ms, P〈0.05）,but was shorter at 9 years old in ADHD group.（ 2） The unrelated condition：the amplitude of normal children aged 10 years was higher than that of other age groups.（ 3） The pesudoword condition：the amplitude of 9 years old normal children was higher than other age groups.The amplitude of ADHD in children aged 9 years was higher than that in other age groups（ （-16.08±7.14）μV, P〈0.05） .Conclusion In the semantic related conditions,the amplitude of the N400 in ADHD children at the age of 8 and the latency at the age of 9 are significantly developed,and in the false words conditions,it is at the age of 11.This suggests that the ability of 7-11 years old ADHD chil-dren＇s orthographic semantic processing and cognitive development are slower than normal.N400 can better reflect the children＇s early language cognitive ability,and it is valuable for the early diagnosis of children with ADHD.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2016年第3期235-239,共5页
Chinese Journal of Behavioral Medicine and Brain Science
