摘要
目的为了研究注意缺陷多动障碍（ADHD）患儿的认知功能,评估ADHD儿童的行为问题,探讨事件相关电位（ERP）P3波与Conners家长量表（CPRS）的相关性。方法选取年龄为8.5~10.5岁的40例ADHD患儿和40例健康对照儿童,进行了听觉ERP P3波的检测,并比较两组家长填写的CPRS结果。用t检验和Bivariate analyze方法分析资料。结果 （1）ADHD组患儿较健康儿童ERP P3波潜伏期延长（P〈0.01）,波幅差异不明显;（2）CPRS评分结果显示ADHD组品行问题、学习问题、心身障碍、冲动-多动和多动指数分量表评分高于对照组,差异有统计学意义（P〈0.01）,焦虑问题分量表分与对照组差异无统计学意义（P〉0.05）;（3）ADHD组和健康对照组ERP P3波的潜伏期与CPRS分量表Ⅱ（学习问题）评分呈显著正相关（r=0.395 1,r=0.3795,P〈0.05）,波幅与CPRS各分量表评分无肯定相关（r=0.007 3~0.213 9,P〉0.05）。（4）28例ADHD患儿经哌甲酯治疗6个月后,ERP P3波的潜伏期缩短（P〈0.01）,CPRS学习问题,冲动-多动,多动指数得分亦降低（P〈0.01）。结论 ADHD患儿存在一定程度认知功能障碍和较多的行为问题,出现学习问题的儿童可能有认知功能损害。事件相关电位检测能为ADHD患儿提供认知功能障碍量化的指标,ERP和CPRS联合使用有助于更客观、全面地评价ADHD。
Objective To study the cognitive functions and assess the behavior problems of children with attention deficit hyperactive disorder（ADHD）,to explore the correlation of Event related potentials（ERP）P3 wave and Conners parent rating scale（CPRS）.Methods 40 cases of ADHD children and 40 cases of healthy children as control group with the age between 8.5 to 10.5 went through auditory event related potentials P3 wave test.The CPRS results of two groups which completed by parents were also compared.Data were analyzed by student T test and Bivariation analyzing method.Results 1.Compared with the control group,the ADHD group had significantly longer latency of P3 wave（P0.01）,while there was not much difference in the amplitude of the P3 wave in the ADHD group.2.In the CPRS investigations,the subscale scores of conduct problem,learning problem,psychosomatic disorder,hyperactivity-impulsion and hyperactivity index were significantly higher in the ADHD group（P0.01）.No significant differences was found between the two groups on the subscale scores of anxiety problem（P0.05）.3.The latencies of P3 wave in the two groups had significantly positive correlation with the scores of CPRS subscaleⅡ（learning problem）（r=0.3951,r=0.3795,P0.05）.However,the relation between the amplitudes of the P3 wave and the scores of each CPRS subscales were not very close（r=0.007 3-0.213 9,P0.05） 4.Compared with before it,the latency of P3 wave significantly shortened and the scores of CPRS subscale of learning problem,hyperactivity-impulsion and hyperactivity index also decreased in the28 children with ADHD after taking methylphenidate six months.Conclusion To some extent,ADHD children have deficits in cognitive functions and more behavior problems.It is demonstrated that children with learning problem may have damage in cognitive function.ERP P3 wave test is a useful method to provide a quantifiable indicator in cognitive deficits of ADHD children,and contributes to evaluate ADHD children objectively and comprehe
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第14期1798-1800,共3页
Chongqing medicine
基金
四川省卫生厅科研计划项目资助课题(010098)
