摘要
TGIF蛋白作为一种核转录抑制因子，功能复杂，不仅能直接抑制靶基因表达，还参与凋控多条重要的细胞信号通路，涉及细胞组织分化、炎症、代谢、肿瘤等方面，特别是近些年来关于TGIF与多种肿瘤的生物学行为方面的研究越来越多，提示TGIF在肿瘤诊治过程中有望成为新的诊断及治疗靶点。本文主要综述了TGIF在TGF—β、MAPK、PI，K／AKT等信号通路以及肝癌、肺癌、尿路上皮癌等多种肿瘤中的研究进展。
As a nuclear transcription repressor, the functions of TGIF are complicated,not only represses target genes expression directly, but also takes part in the regulation of multiple important cellular signaling pathways, which are associated with the differentiation of cells and tissues, inflammation, metabolism and tumors. In past fewyears, more and more studies on the role of TGIF in tumors suggest TGIF may be a new therapy target in the diagnosis and treatment of tumours. This article mainly reviews the research progress of TGIF in some signaling pathways like TGF-β, MAPK, PI3K/AKT, and tumours like hepatocellular carcinoma, lung carcinoma and urinary tract urothelial carcinoma.
出处
《国际外科学杂志》
2016年第2期128-132,共5页
International Journal of Surgery
基金
国家自然科学基金（U1204815）
河南省高校科技创新人才支持计划（14HASTIT030）
