摘要
目的:探讨TGIF(TG interacting factor)蛋白在食管癌中的表达水平及其临床病理意义. 方法:应用免疫组织化学SP法,对32例食管癌的活检和手术切除标本进行抗人TGIF抗体免疫组织化学染色,检测癌组织和癌旁组织TGIF的表达,并分析TGIF的表达与食管癌临床病理特征之间的关系. 结果:TGIF在食管黏膜鳞状上皮和食管癌组织中阳性率分别为60.0%和71.2%,但后者以中度-强阳性为主.TGIF 蛋白在食管癌组织中的表达水平明显高于正常食管黏膜鳞状上皮(P=0.036),但与性别、肿瘤的分化、浸润深度及淋巴结的转移无关. 结论:TGIF通过抑制TGF-β和视黄醛促进食管癌的发生与发展.
AIM: To investigate the expression level of TG interacting factor (TGIF) in esophageal carcinomas, and the correlation between TGIF and clinicopathological features of esophageal carcinoma. METHODS: A total of 32 specimens of esophageal carcinoma were investigated by immunohistochemical staining with a polyclonal antibody against TGIF. The expression of TGIF in esophageal carcinoma was detected and the relationship between the expression of TGIF and clinico-patho-logical features of esophageal carcinoma was analyzed. RESULTS: The positive rates of TGIF in normal esophageal squamous epithelium and esophageal carcinoma were 60% and 71.2%, respectively, but the latter had stronger intensity staining. The expression level of TGIF in esophageal carcinoma was higher than that in normal esophageal squamous epithelium (P=0.036), but had no correlation with gender, depth of invasion, tumor grade and lymph node metastasis. CONCLUSION: TGIF is a possible oncogene, and it may promote the progression of esophageal carcinomas via inhibiting both the TGF-β and retinoid signaling pathways.
出处
《世界华人消化杂志》
CAS
2004年第8期1766-1768,共3页
World Chinese Journal of Digestology
