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动脉粥样硬化斑块稳定性与γ-干扰素及受体基因多态性的发展前景 被引量:1

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摘要 动脉粥样硬化斑块的不稳定导致斑块破裂、血栓形成及血管阻塞,是发生急性心、脑血管事件的主要原因,其各阶段存在慢性炎症和免疫反应。γ-干扰素是多功能细胞因子,是巨噬细胞、自然杀伤细胞、血管内皮细胞的活化剂,且具有阻止胶原蛋白合成,抗纤维化作用。某些基因位点上的多态性会影响基因的转录效率和/或表达产物的功能,但γ-干扰素及受体基因多态性是否影响动脉粥样硬化的发生及其斑块稳定性尚不十分清楚,探讨其作为预警指标有良好的发展前景。
出处 《中国临床实用医学》 2016年第1期100-102,共3页 China Clinical Practical Medicine
基金 云南省科技厅应用基础研究计划青年项目(2013FD093)
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